Alam Md Ashraful
Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.
Front Nutr. 2019 Aug 7;6:121. doi: 10.3389/fnut.2019.00121. eCollection 2019.
Ferulic acid is a simple phenolic acid found mainly in cereals and grains, used as an antioxidant and food preservative. Recent evidence suggests that ferulic acid possess anti-inflammatory, anti-diabetic, anticancer, and cardioprotective properties. Several investigations also have shown that ferulic acid rich food might prevent hypertension. As a potent scavenger of free radicals (ROS, reactive oxygen species), ferulic acid attenuates oxidative stress, which is responsible for lowering elevated blood-pressure through improved endothelial function and increased bioavailability of the nitric oxide in the arterial vasculature. This review article describes the role of ferulic acid in the pathophysiology of vascular dysfunction and hypertension along with highlighted the merit of further scientific and clinical exploration.
阿魏酸是一种主要存在于谷物中的简单酚酸，用作抗氧化剂和食品防腐剂。最近的证据表明，阿魏酸具有抗炎、抗糖尿病、抗癌和心脏保护特性。多项研究还表明，富含阿魏酸的食物可能预防高血压。作为一种有效的自由基（ROS，活性氧）清除剂，阿魏酸可减轻氧化应激，氧化应激通过改善内皮功能和增加动脉血管中一氧化氮的生物利用度来降低血压升高。这篇综述文章描述了阿魏酸在血管功能障碍和高血压病理生理学中的作用，并强调了进一步进行科学和临床探索的价值。
