Le Blanc Jessica, Lordkipanidzé Marie
Research Center, Montreal Heart Institute, Montreal, QC, Canada.
Faculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.
Front Cardiovasc Med. 2019 Aug 7;6:109. doi: 10.3389/fcvm.2019.00109. eCollection 2019.
Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that platelet aggregability is increased in vascular diseases, the contribution of age-related changes in platelet biology to cardiovascular risk is not well-understood. Several lines of evidence support that platelets from older subjects differ in their function and structure, making platelets more prone to activation and less sensitive to inhibition. These age-related changes could lead to platelet hyperactivity and to the development of a prothrombotic state in advanced age. This review will focus on platelet biochemical modifications during aging and on the mechanisms by which these alterations could lead to thrombotic disease.
衰老与心血管疾病和血栓形成的发病率增加有关。血小板在维持止血和血栓形成中起主要作用，使其成为血栓性疾病的关键因素。虽然众所周知血管疾病中血小板聚集性增加，但血小板生物学中与年龄相关的变化对心血管风险的影响尚不清楚。有几条证据支持老年受试者的血小板在功能和结构上存在差异，使血小板更容易被激活且对抑制作用不敏感。这些与年龄相关的变化可能导致血小板活性过高，并在老年时发展为血栓前状态。本综述将聚焦于衰老过程中血小板的生化修饰以及这些改变可能导致血栓性疾病的机制。
