Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Genetics, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Fetal Pediatr Pathol. 2020 Oct;39(5):373-380. doi: 10.1080/15513815.2019.1655819. Epub 2019 Aug 26.
Preeclampsia (PE) is one of the main causes of fetal and maternal mortality. The analysis of candidate gene polymorphisms can improve our understanding of the mechanisms underlying pathogenesis of PE. Present study is aimed at investigating the association between c.66A > G, c.677C > T, c.1298A > C, and c.2756A > G polymorphisms and PE in Iranian women. About 117 women with history of PE and 103 healthy women with a pregnancy not complicated by PE were selected. The genomic DNA was extracted from peripheral blood. Single-nucleotide polymorphisms were genotyped using Real-Time PCR. There was a significant difference between c.677C > T polymorphism with PE ( = 0.045). The frequency of C/T heterozygous genotypes were (58% vs. 36%) in the case and control groups, respectively. There were no statistically significant differences between other genetic polymorphisms. The results indicated that the c.677C > T polymorphism may be associated with development of PE in Iranian women.
子痫前期 (PE) 是胎儿和产妇死亡的主要原因之一。候选基因多态性的分析可以帮助我们更好地理解 PE 发病机制。本研究旨在探讨 c.66A>G、c.677C>T、c.1298A>C 和 c.2756A>G 多态性与伊朗女性 PE 之间的关系。选择了 117 名有 PE 病史的女性和 103 名未合并 PE 的健康孕妇作为对照。从外周血中提取基因组 DNA。采用实时 PCR 技术对单核苷酸多态性进行基因分型。c.677C>T 多态性与 PE 之间存在显著差异（P=0.045）。病例组和对照组 C/T 杂合基因型的频率分别为（58% vs. 36%）。其他遗传多态性之间无统计学差异。结果表明，c.677C>T 多态性可能与伊朗女性 PE 的发生有关。
