Friteau L, Francesconi E, Lando D, Dugas B, Damais C
Département de Biotechnologies, CNRS/Roussel, Romainville, France.
Biochem Biophys Res Commun. 1988 Dec 30;157(3):1197-204. doi: 10.1016/s0006-291x(88)81001-5.
Stimulated monocytes produce prostaglandins (PGE2) in response to lipopolysaccharide (LPS), Muramyl dipeptide (MDP) or Interleukin-1 (IL-1). This response could be modulated in different ways by Interferon-gamma (IFN-gamma). This lymphokine, known to potentiate IL-1 production by LPS- or MDP-stimulated monocytes, suppressed different Il-1 activities such as PGE2 release by the same cells. By contrast, an impairement of suppression by IFN-gamma was evidenced in rIL-1 beta-induced PGE2 release from human dermal fibroblasts. Salmon calcitonin (sCT), another inhibitor of IL-1-induced bone resorption, was able to prime monocytes to potentiate PGE2 elaboration by LPS, but failed to modulate PGE2 liberation from either rIL-1 beta-stimulated monocytes or fibroblasts.
受到刺激的单核细胞会响应脂多糖（LPS）、胞壁酰二肽（MDP）或白细胞介素-1（IL-1）产生前列腺素（PGE2）。干扰素-γ（IFN-γ）可以通过不同方式调节这种反应。这种淋巴因子已知可增强LPS或MDP刺激的单核细胞产生IL-1，但会抑制同一细胞的不同IL-1活性，如PGE2释放。相比之下，在重组人IL-1β诱导人皮肤成纤维细胞释放PGE2的过程中，IFN-γ的抑制作用受损。鲑鱼降钙素（sCT）是另一种IL-1诱导骨吸收的抑制剂，它能够使单核细胞致敏，增强LPS诱导的PGE2生成，但无法调节重组人IL-1β刺激的单核细胞或成纤维细胞释放PGE2。
