Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Public Health, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Diabetes Res Clin Pract. 2019 Oct;156:107826. doi: 10.1016/j.diabres.2019.107826. Epub 2019 Aug 23.
To systematically assess the association between depression and risk of gestational diabetes by a meta-analysis of cohort studies.
We searched multiple electronic databases for cohort studies investigating depression and risk of gestational diabetes before December 31th, 2018. Pooled odds ratios (ORs) and confidence intervals (CIs) of the included articles were calculated using a fixed- or random-effect model. Publication bias was detected using the Egger's and Begg's tests.
We obtained 5 cohort studies with a total number of 122,197 women. Women with a history of depression compared with those without it had a significantly increased risk of gestational diabetes (pooled OR = 1.20, 95% CI: 1.09, 1.33) but borderline significant evidence of heterogeneity was observed (I = 45.1%, P for heterogeneity = 0.12). Subgroup analysis by study design showed a stronger association in prospective cohort studies than that in retrospective cohort studies (pooled OR: 1.61 [1.17, 2.21] vs. 1.16 [1.05, 1.29]), though the difference was not statistically significant (P for interaction = 0.26). We observed some evidence of publication bias; however, correction for such bias using "trim-and-fill" analysis yielded similar results.
Women with a history of depression may be at an increased risk of gestational diabetes. Future prospective studies of high quality are needed to confirm our findings.
通过对队列研究的荟萃分析，系统评估抑郁与妊娠期糖尿病风险之间的关系。
我们在多个电子数据库中搜索了截至 2018 年 12 月 31 日调查抑郁与妊娠期糖尿病风险的队列研究。使用固定或随机效应模型计算纳入研究的汇总优势比（OR）和置信区间（CI）。使用 Egger 和 Begg 检验检测发表偏倚。
我们获得了 5 项队列研究，共有 122197 名女性。与没有抑郁史的女性相比，有抑郁史的女性患妊娠期糖尿病的风险显著增加（汇总 OR=1.20，95%CI：1.09，1.33），但存在明显的异质性（I=45.1%，P 异质性=0.12）。按研究设计进行的亚组分析显示，前瞻性队列研究的相关性强于回顾性队列研究（汇总 OR：1.61 [1.17，2.21] 与 1.16 [1.05，1.29]），尽管差异无统计学意义（P 交互=0.26）。我们观察到存在发表偏倚的一些证据；然而，使用“修剪和填充”分析校正这种偏倚得出了相似的结果。
有抑郁史的女性可能患妊娠期糖尿病的风险增加。需要进行高质量的前瞻性研究来证实我们的发现。
