Department of Food Science and Nutrition, Dong A University, Busan, 49315, South Korea; Center for Silver-targeted Bimaterials, Brain Busan 21 Plus program, Dong A University, Busan, 49315, South Korea.
Department of Neurology, Chosun University Medical School, Gwangju, 61452, Republic of Korea.
Pharmacol Res. 2019 Oct;148:104411. doi: 10.1016/j.phrs.2019.104411. Epub 2019 Aug 23.
Obesity is a globally widespread metabolic disorder, characterized by immoderate fat accumulation in the body. There are different types of body fats such as white adipose tissue (WAT), which stores surplus energy in the body, and brown adipose tissue (BAT) which utilize energy to produce heat during metabolism. BAT acts many beneficial functions in metabolic disorders including type 2 diabetes and obesity. Recent studies have investigated methods for promoting the fat browning process of WAT in obesity because of various reasons such as the improvement of insulin resistance, and weight loss. Among natural polyphenolic compounds, resveratrol has been highlighted due to its anti-oxidant and anti-obesity as well as anti-inflammation and anti-cancer properties. Recent studies have paid a lot of attention to that resveratrol may act as a fat browning activator, involved in the secretion of many myokines and adipokines. Here, we reviewed the role of resveratrol in fat browning and also the association between resveratrol and adipokines/myokines in the fat browning process. Our review may provide novel insight into the role of resveratrol in fat browning, leading to the maintenance of a healthy weight against obesity.
肥胖是一种全球范围内广泛存在的代谢紊乱，其特征是体内脂肪过度积累。有不同类型的体脂，如白色脂肪组织（WAT），它将多余的能量储存在体内，而棕色脂肪组织（BAT）则在代谢过程中利用能量产生热量。BAT 在代谢紊乱中具有许多有益的功能，包括 2 型糖尿病和肥胖症。由于改善胰岛素抵抗和减肥等多种原因，最近的研究已经探讨了促进肥胖症中 WAT 脂肪褐变过程的方法。在天然多酚化合物中，白藜芦醇因其抗氧化、抗肥胖、抗炎和抗癌特性而备受关注。最近的研究已经非常关注白藜芦醇可能作为一种脂肪褐变激活剂，参与许多肌因子和脂肪因子的分泌。在这里，我们综述了白藜芦醇在脂肪褐变中的作用，以及白藜芦醇与脂肪因子/肌因子在脂肪褐变过程中的关联。我们的综述可能为白藜芦醇在脂肪褐变中的作用提供新的见解，有助于保持健康的体重，预防肥胖。
