College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan.
Biofactors. 2018 Jan;44(1):50-60. doi: 10.1002/biof.1409. Epub 2018 Jan 5.
Obesity is a current global epidemic that has led to a marked increase in metabolic diseases. However, its treatment remains a challenge. Obesity is a multifactorial disease, which involves the dysfunction of neuropeptides, hormones, and inflammatory adipokines from the brain, gut, and adipose tissue. An understanding of the mechanisms and signal interactions in the crosstalk between organs and tissue in the coordination of whole-body energy metabolism would be helpful to provide therapeutic and putative approaches to the treatment and prevention of obesity and related complications. Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health. In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies. Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity. Although the efficacy of both compounds in humans requires further investigation with respect to their oral bioavailability, promising scientific findings have highlighted their potential as candidates for the treatment of obesity and the improvement of obesity-related metabolic diseases. © 2018 BioFactors, 44(1):50-60, 2018.
肥胖是当前的全球性流行病，导致代谢性疾病显著增加。然而，其治疗仍然是一个挑战。肥胖是一种多因素疾病，涉及来自大脑、肠道和脂肪组织的神经肽、激素和炎症脂肪因子的功能障碍。了解器官和组织之间相互作用的机制和信号相互作用，以及协调全身能量代谢的机制，将有助于提供治疗和预防肥胖及相关并发症的治疗和潜在方法。白藜芦醇和紫檀芪是众所周知的芪类化合物，对人类健康有多种潜在益处。特别是，它们在许多细胞培养和动物研究中已被证明具有潜在的抗肥胖作用。这两种化合物通过靶向多种分子和信号通路，调节能量摄入、脂肪细胞生命周期和功能、白色脂肪组织（WAT）炎症、能量消耗和肠道微生物群，作为肥胖的干预措施。尽管这两种化合物在人类中的疗效还需要进一步研究其口服生物利用度，但有前途的科学发现强调了它们作为肥胖治疗和改善肥胖相关代谢性疾病候选药物的潜力。
