Platelet count and mean platelet volume predict atypical pre-eclampsia.

OBJECTIVE

We aimed to analyze the role of platelet count (PC), mean platelet volume (MPV), and ratio of PC to MPV (PC/MPV) in predicting and/or diagnosing atypical pre-eclampsia (PE).

STUDY DESIGN

We performed a retrospective case-control analysis of these platelet parameters in healthy pregnant women with normal blood pressure (control) and the changes that occurred in patients with atypical PE and PE.

MAIN OUTCOME MEASURES

We performed statistical analysis to evaluate the prognostic and predictive significance of PC, MPV, and PC/MPV and the combined effects of these parameters in the parturient population (N = 300) composed of 100 controls, 100 atypical PE cases, and 100 PE cases.

RESULTS

The PC, MPV, and PC/MPV in both atypical PE and PE were significantly different to that in the controls. After adjusting for confounding factors using the ordinal logistics regression model, we found that PC/MPV, N% and BMI were independent risk factors for PE and atypical PE(The odds ratio was 0.925, 1.028 and 1.071). The model's C-index is 0.684.

CONCLUSION

We found that the PC, MPV, and PC/MPV may be changed in atypical PE patients who did not have significant PE symptoms. Our results indicated that it could be a diagnostic method to predict atypical PE during pregnancy. PC/MPV and the other platelet parameters can play a role in predicting the development of atypical PE, leading to better diagnosis and management of atypical PE.