子痫前期与血小板计数和血小板平均体积均有关：系统评价和荟萃分析。
Preeclampsia has an association with both platelet count and mean platelet volume: A systematic review and meta-analysis.
机构信息
Medicallaboratory Science Department, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Ethiopia.
Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
PLoS One. 2022 Sep 14;17(9):e0274398. doi: 10.1371/journal.pone.0274398. eCollection 2022.
BACKGROUND
Preeclampsia (PE) is a pregnancy-specific disorder characterized by endothelial dysfunction, and activation of the coagulation system. Alteration of PLT parameters is the common hematological abnormality observed in women with PE. The main aim of this study was to systematically review previous studies from around the world to generate evidence about the relationship between platelet count (PC) and PE, as well as mean platelet volume (MPV) and PE, by calculating the pooled weighted mean difference (WMD) of PC and MPV between PE and normotensive (NT) groups.
METHODS
Relevant articles which were published in the English language from January 10, 2011, to January 10, 2021, were systematically searched through PubMed, Web of Science, and African journals online. In addition, reference probing of published articles searching was employed through Google Scholar and Google for searching grey literature. The methodological qualities of articles were assessed using Joana Brigg's institute critical appraisal checklist. A random-effects model was used to estimate pooled WMD of PLT parameters between the two groups with the respective 95% confidence intervals (CI) using Stata version 11.0. The I2 statistics and Egger's regression test were used to assess heterogeneity and publication bias among included studies, respectively.
RESULTS
A total of 25 articles were included in this systematic review and meta-analysis. Of which, 23 studies were used in each PC and MPV analysis. The overall pooled WMD of PC and MPV between PE and NT groups were -41.45 × 109/L [95% CI; -51.8, -31.0] and 0.98 fl [95% CI; 0.8, 1.1], respectively. The pooled WMD revealed that PC decreased significantly in the PE group compared to the NT group while MPV increased significantly in the PE group.
CONCLUSIONS
This systematic review and meta-analysis indicated that there is a significant decrease in PC and a significant increase in MPV during PE development among pregnant women. As a result, a change in these parameters among pregnant women may indicate the development of PE.
背景
子痫前期（PE）是一种妊娠特有的疾病，其特征为内皮功能障碍和凝血系统激活。血小板参数的改变是子痫前期患者常见的血液学异常。本研究的主要目的是系统地综述来自世界各地的以往研究，以计算子痫前期组与正常血压（NT）组之间血小板计数（PC）和平均血小板体积（MPV）的汇总加权均数差（WMD），从而生成关于 PC 和 MPV 与子痫前期之间关系的证据。
方法
通过 PubMed、Web of Science 和 African journals online 系统地检索了 2011 年 1 月 10 日至 2021 年 1 月 10 日发表的英文文献。此外，还通过 Google Scholar 和 Google 检索了已发表文章的参考文献，以查找灰色文献。使用 Joana Brigg 研究所的批判性评价清单评估文章的方法学质量。使用 Stata 版本 11.0 采用随机效应模型来估计两组之间 PLT 参数的汇总 WMD，置信区间（CI）分别为 95%。采用 I2 统计量和 Egger 回归检验分别评估纳入研究的异质性和发表偏倚。
结果
共有 25 篇文章纳入本系统综述和荟萃分析。其中，PC 和 MPV 分析各有 23 项研究。PE 组与 NT 组之间的 PC 和 MPV 的总体汇总 WMD 分别为-41.45×109/L[95%CI；-51.8，-31.0]和 0.98 fl[95%CI；0.8，1.1]。汇总 WMD 表明，PE 组的 PC 明显低于 NT 组，而 MPV 明显高于 PE 组。
结论
本系统综述和荟萃分析表明，孕妇子痫前期时 PC 显著降低，MPV 显著升高。因此，孕妇这些参数的变化可能提示 PE 的发生。
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