Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Research Centre of Excellent, Nutrition and Non-Communicable Diseases (NNCD), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Int J Mol Sci. 2019 Aug 23;20(17):4114. doi: 10.3390/ijms20174114.
A nanocomposite, phytic acid-chitosan-magnetic iron oxide nanoparticles (IP-CS-MNPs) has been used to treat colon cancer in vitro, previously. However, its potential toxicity in vivo has yet to be elucidated. Hence, the present study aimed to evaluate the acute effects of oral administration of IP-CS-MNPs in mice. In this study, 1000 and 2000 mg/kg body weight (b.w) of IP-CS-MNPs were orally administered to two different groups of BALB/c mice, once. Additionally, the mice in the control group were given only deionized water. After 14 days of post-IP-CS-MNPs administration, in a similar way to the untreated mice, the treated mice showed no sign of mortality and abnormalities. However, the serum urea level of mice receiving 2000 mg/kg b.w of IP-CS-MNPs was significantly higher than the control group ( < 0.05). The mice that received 1000 mg/kg IP-CS-MNPs showed a significantly higher level of serum alkaline phosphatase (ALP) compared to the control group. However, there were no significant histopathological changes seen in the liver and kidneys of treated mice compared to the untreated group.
先前有研究使用纳米复合材料植酸壳聚糖-磁性氧化铁纳米粒子（IP-CS-MNPs）在体外治疗结肠癌，但它在体内的潜在毒性尚未阐明。因此，本研究旨在评估 IP-CS-MNPs 经口给予小鼠的急性作用。在这项研究中，将 1000 和 2000mg/kg 体重的 IP-CS-MNPs 分别以口服的方式给予两组 BALB/c 小鼠，而对照组的小鼠仅给予去离子水。在给予 IP-CS-MNPs 后的 14 天内，与未处理的小鼠一样，处理组的小鼠没有出现死亡和异常的迹象。然而，接受 2000mg/kg 体重 IP-CS-MNPs 的小鼠的血清尿素水平明显高于对照组（<0.05）。与对照组相比，接受 1000mg/kg IP-CS-MNPs 的小鼠的血清碱性磷酸酶（ALP）水平显著升高。然而，与未处理组相比，处理组的小鼠的肝和肾组织未见明显的组织病理学变化。
