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Massive infected ascites in an immunocompetent patient with gastrointestinal tuberculosis.一名免疫功能正常的胃肠道结核患者出现大量感染性腹水。
BMJ Case Rep. 2019 Aug 26;12(8):e230794. doi: 10.1136/bcr-2019-230794.
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本文引用的文献

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Abdominal tuberculosis: Is there a role for surgery?腹部结核:手术有作用吗?
World J Gastrointest Surg. 2017 Aug 27;9(8):174-181. doi: 10.4240/wjgs.v9.i8.174.
2
Microbiome Changes during Tuberculosis and Antituberculous Therapy.结核病及抗结核治疗期间的微生物组变化
Clin Microbiol Rev. 2016 Oct;29(4):915-26. doi: 10.1128/CMR.00096-15. Epub 2016 Sep 8.
3
Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.微褶细胞主动转运结核分枝杆菌以引发感染。
Cell Rep. 2016 Aug 2;16(5):1253-1258. doi: 10.1016/j.celrep.2016.06.080. Epub 2016 Jul 21.
4
Abdominal tuberculosis of the gastrointestinal tract: revisited.胃肠道结核:再探讨
World J Gastroenterol. 2014 Oct 28;20(40):14831-40. doi: 10.3748/wjg.v20.i40.14831.
5
Tuberculous peritonitis: analysis of 211 cases in Taiwan.结核性腹膜炎:台湾 211 例病例分析。
Dig Liver Dis. 2012 Feb;44(2):111-7. doi: 10.1016/j.dld.2011.08.020. Epub 2011 Sep 25.
6
Tuberculous peritonitis in cirrhotic patients: comparison of spontaneous bacterial peritonitis caused by Escherichia coli with tuberculous peritonitis.肝硬化患者的结核性腹膜炎:大肠杆菌所致自发性细菌性腹膜炎与结核性腹膜炎的比较
Scand J Infect Dis. 2009;41(11-12):852-6. doi: 10.3109/00365540903214264.
7
Abdominal tuberculosis in southeastern Taiwan: 20 years of experience.台湾东南部的腹部结核:20年经验
J Formos Med Assoc. 2009 Mar;108(3):195-201. doi: 10.1016/S0929-6646(09)60052-8.
8
Spontaneous bacterial peritonitis.自发性细菌性腹膜炎
Postgrad Med J. 2007 Jun;83(980):379-83. doi: 10.1136/pgmj.2006.056168.

一名免疫功能正常的胃肠道结核患者出现大量感染性腹水。

Massive infected ascites in an immunocompetent patient with gastrointestinal tuberculosis.

作者信息

Saliba Carmegie C, Tomacruz Isabelle Dominique Villegas, Javier Mary Louise Margaret M, Co Homer

机构信息

Department of Medicine, University of the Philippines Manila, Manila, Metro Manila, Philippines.

College of Medicine, University of the Philippines Manila, Manila, Metro Manila, Philippines.

出版信息

BMJ Case Rep. 2019 Aug 26;12(8):e230794. doi: 10.1136/bcr-2019-230794.

DOI:10.1136/bcr-2019-230794
PMID:31451473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6720565/
Abstract

is highly endemic in the Philippines. The diagnosis is challenging with its non-specific presentation and the organism could extend to any of the organs. Interestingly, bacterial peritonitis arising spontaneously from gastrointestinal tuberculosis (TB) in an otherwise healthy, non-cirrhotic patient is quite unusual. In this paper, we discuss the case of a 27-year-old HIV-seronegative woman with massive intraperitoneal mixed bacterial and tuberculous abscess presenting 20 months after being diagnosed with bacteriologically confirmed gastrointestinal TB. Repeated large-volume paracentesis was done to drain out the infected ascites instead of inserting a percutaneously implanted catheter. Clinical improvement was noted and she was discharged after 12 days of intravenous antibiotics. She had completed 6 months of antituberculosis therapy and been well since then. The case has demonstrated that repeated paracentesis along with appropriate antibiotic regimen, may be a viable option for patients with TB and bacterial coinfected peritonitis. And possibly, peritoneal TB may increase the risk for (spontaneous) bacterial peritonitis.

摘要

在菲律宾高度流行。由于其表现不具特异性,诊断具有挑战性,而且该病菌可累及任何器官。有趣的是,在一名原本健康、无肝硬化的患者中,由胃肠道结核(TB)自发引起的细菌性腹膜炎相当罕见。在本文中,我们讨论了一名27岁HIV血清阴性女性的病例,该患者在被细菌学确诊为胃肠道结核20个月后,出现大量腹腔内混合细菌性和结核性脓肿。采用反复大量腹腔穿刺放液来引流感染性腹水,而不是插入经皮植入导管。观察到临床症状改善,静脉使用抗生素12天后出院。她已完成6个月的抗结核治疗,此后情况良好。该病例表明,对于结核和细菌合并感染性腹膜炎患者,反复腹腔穿刺放液联合适当的抗生素治疗方案可能是一种可行的选择。而且,腹膜结核可能会增加(自发性)细菌性腹膜炎的风险。