Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Cold Spring Harb Perspect Med. 2019 Dec 2;9(12):a034868. doi: 10.1101/cshperspect.a034868.
The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) a little over a decade ago raised exciting prospects to transform the study and potentially also the therapy of human diseases. iPSC models have now been created for a multitude of hematologic diseases, including malignancies. Here we discuss practical aspects of iPSC modeling of malignant diseases, review recent studies, and discuss the new opportunities that iPSC models offer, as well as their current limitations and prospects for future development.
十多年前，人类体细胞重编程为诱导多能干细胞（iPSCs），这为人类疾病的研究和治疗带来了令人振奋的前景。现在已经为多种血液系统疾病（包括恶性肿瘤）建立了 iPSC 模型。在这里，我们讨论恶性疾病的 iPSC 建模的实际方面，回顾最近的研究，并讨论 iPSC 模型带来的新机会，以及它们目前的局限性和未来发展的前景。
