Steinmann-Zwicky M
Zoological Institute, University of Zürich, Switzerland.
EMBO J. 1988 Dec 1;7(12):3889-98. doi: 10.1002/j.1460-2075.1988.tb03275.x.
In Drosophila, females require products of the gene Sxl for sex determination, dosage compensation and fertility. I show here that the X-chromosomal gene liz, located in 4F1 to 4F11 and previously called fs(1)1621, provides maternal and zygotic functions necessary for Sxl activity in germ line and soma. In XX animals, the mutation SxlM1 which was reported to express the female-specific functions of Sxl constitutively can rescue all phenotypes resulting from lack of liz product. XY animals carrying SxlM1 and lacking maternal or zygotic liz activity survive as males with some female traits. A stock was constructed in which the females are liz SxlM1/liz SxlM1 and males liz SxlM1/Y. This shows that SxlM1 is not truly expressed constitutively in animals with an X:A ratio of 0.5, but requires activity of liz for initiation or maintenance.
在果蝇中，雌性果蝇的性别决定、剂量补偿和生育能力需要Sxl基因的产物。我在此表明，位于4F1至4F11的X染色体基因liz（先前称为fs(1)1621）为生殖系和体细胞中Sxl活性提供了母体和受精卵功能。在XX动物中，据报道能组成性表达Sxl雌性特异性功能的突变SxlM1可以挽救因缺乏liz产物而产生的所有表型。携带SxlM1且缺乏母体或受精卵liz活性的XY动物作为具有一些雌性特征的雄性存活。构建了一个品系，其中雌性为liz SxlM1/liz SxlM1，雄性为liz SxlM1/Y。这表明，在X:A比例为0.5的动物中，SxlM1并非真正组成性表达，而是需要liz的活性来启动或维持。
