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肠外营养而非早期手术在治疗术后早期小肠梗阻中的应用。

Parenteral Nutrition Instead of Early Reoperation in the Management of Early Postoperative Small Bowel Obstruction.

机构信息

Digestive Diseases and Surgery Institute, Cleveland Clinic, 9500 Euclid Ave Desk A100, Cleveland, OH, 44195, USA.

Division of Colon and Rectal Surgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

出版信息

J Gastrointest Surg. 2020 Jan;24(1):109-114. doi: 10.1007/s11605-019-04347-1. Epub 2019 Aug 26.

DOI:10.1007/s11605-019-04347-1
PMID:31452077
Abstract

BACKGROUND

In majority of patients, early postoperative small bowel obstruction (EPSBO) resolves with nasogastric decompression and bowel rest alone, while in some patients, symptoms persist without urgent indications for surgery. The purpose of this study was the evaluation of home parenteral nutrition (HPN) instead of elective surgery as an initial approach to persistent EPSBO.

METHODS

Patients developing EPSBO prescribed HPN without reoperation within 6 weeks after index intestinal surgery were identified from an institutional HPN registry and retrospectively compared with patients undergoing reoperation for EPSBO within the same time period.

RESULTS

Thirty-four patients for the HPN group and 27 patients in elective reoperative (REOP) group met the inclusion criteria. In the HPN group, mean interval between surgery and PN initiation was 11 days. HPN duration ranged from 17 to 244 days with a median of 60 days. Thirty-one patients (91%) successfully recovered bowel function and resumed enteral nutrition without reoperation, while 3 patients required reoperation > 6 weeks after index surgery due to HPN failure. In the REOP group, mean interval between index surgery and reoperation was 17 days. At reoperation, 12 patients required bowel resection, 5 having incidental enterotomies, and 3 required new stoma creation. Postoperatively, 2 patients developed enterocutaneous fistulas, 1 experienced an anastomotic leak, and another had fascial dehiscence.

CONCLUSION

HPN is a safe alternative to elective surgery in clinically stable patients with persistent EPSBO. This approach avoids hazardous reoperation during the recovery phase when adhesions are at their worst.

摘要

背景

在大多数患者中,早期术后小肠梗阻(EPSBO)仅通过鼻胃减压和肠休息即可自行缓解,而在一些患者中,症状持续存在而没有紧急手术指征。本研究的目的是评估家庭肠外营养(HPN)作为持续性 EPSBO 的初始治疗方法,而非选择手术。

方法

从机构 HPN 登记处中确定在索引肠道手术后 6 周内未再次手术而发生 EPSBO 的患者,并回顾性地将其与在同一时期内因 EPSBO 而行择期再手术的患者进行比较。

结果

HPN 组有 34 例患者,择期再手术(REOP)组有 27 例患者符合纳入标准。在 HPN 组中,手术与 PN 开始之间的平均间隔为 11 天。HPN 持续时间从 17 天到 244 天不等,中位数为 60 天。31 例(91%)患者成功恢复肠功能并在无需再次手术的情况下恢复肠内营养,而 3 例患者由于 HPN 失败而在索引手术后 >6 周时需要再次手术。在 REOP 组中,手术与再手术之间的平均间隔为 17 天。在再手术时,12 例患者需要肠切除,5 例患者出现意外肠切开,3 例患者需要新造口。术后,2 例患者发生肠外瘘,1 例患者发生吻合口漏,另 1 例患者发生筋膜裂开。

结论

在临床稳定的持续性 EPSBO 患者中,HPN 是择期手术的安全替代方法。这种方法避免了在粘连最严重的恢复期进行危险的再次手术。

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Making inferences on treatment effects from real world data: propensity scores, confounding by indication, and other perils for the unwary in observational research.
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Ethanol lock therapy in reducing catheter-related bloodstream infections in adult home parenteral nutrition patients: results of a retrospective study.乙醇封管疗法在降低成人家庭肠外营养患者导管相关血流感染中的应用:一项回顾性研究的结果。
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