人体心脏的体内钾磁共振成像。
In vivo potassium MRI of the human heart.
机构信息
Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
出版信息
Magn Reson Med. 2020 Jan;83(1):203-213. doi: 10.1002/mrm.27951. Epub 2019 Aug 27.
PURPOSE
Potassium ions (K ) play a critical role in cardiac electrophysiology, and changes in their concentration reflect pathophysiological processes related to cardiovascular diseases. Here, we investigated the feasibility of in vivo K MRI of the human heart. To achieve this, we developed, evaluated, and applied a K/ H RF coil, which is tailored for K MRI of human heart at 7.0T.
METHODS
The performance of the K/ H RF coil was evaluated by electromagnetic field and specific absorption ratio simulations using 2 (male/female) human voxel models. The RF coil was evaluated at the bench and applied in an in vivo proof-of-principle study involving 7 healthy volunteers. The experiments were performed using a 7.0T whole-body MR system in conjunction with a 3D density-adapted projection reconstruction imaging technique.
RESULTS
For in vivo K MRI of the human heart, a nominal spatial resolution of 14.5 × 14.5 × 14.5 mm within a total scan time of 30 min was achieved. The average SNR within the heart was 9.6 ± 2.4.
CONCLUSION
This work validates the design of a K/ H RF coil for cardiac MR at 7.0T and demonstrates for the first time in vivo the feasibility of K MRI of the human heart.
目的
钾离子（K ）在心脏电生理学中起着至关重要的作用，其浓度的变化反映了与心血管疾病相关的病理生理过程。在这里，我们研究了在体人心肌 K 磁共振成像的可行性。为此，我们开发、评估并应用了一种针对 7.0T 人心肌 K 磁共振成像的 K / H RF 线圈。
方法
使用 2 个人体体素模型（男性/女性）进行电磁场和特定吸收率模拟，评估 K / H RF 线圈的性能。在台架上评估 RF 线圈，并将其应用于涉及 7 名健康志愿者的体内原理验证研究中。实验在 7.0T 全身磁共振系统上进行，结合三维密度自适应投影重建成像技术。
结果
对于人心肌的在体 K 磁共振成像，在 30 分钟的总扫描时间内实现了 14.5 × 14.5 × 14.5mm 的名义空间分辨率。心脏内的平均 SNR 为 9.6 ± 2.4。
结论
这项工作验证了用于 7.0T 心脏磁共振的 K / H RF 线圈的设计，并首次在体内证明了人心肌 K 磁共振成像的可行性。
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