Sandyk R, Bamford C R, Binkiewicz A, Finley P R
Department of Neurology, University of Arizona, Tucson 85724.
Int J Neurosci. 1988 Sep;42(1-2):121-5. doi: 10.3109/00207458808985766.
Plasma baseline levels of gonadotropins and sex steroids were measured in 17 patients with Tourette's Syndrome (TS). In addition, a Gonadotropin Stimulation test, using a synthetic Gonadotropin releasing factor analogue (GnRH, 100 micrograms, i.v.), was performed in 7 patients. Plasma levels of Luteinizing Hormone (LH) were uniformly low in all patients, while those of Follicle Stimulating hormone (FSH) and sex steroids were less depressed in some patients and in the normal range in others. In all patients, stimulation with GnRH analogue produced a marked rise in LH levels, but the FSH responses were much less dramatic and did not significantly exceed that of normal controls. Our findings indicate reduced gonadotropin release in patients with TS, and support the hypothesis of hypothalamic involvement in the disease.
对17例图雷特综合征（TS）患者测定了血浆促性腺激素和性类固醇的基线水平。此外，对7例患者进行了促性腺激素刺激试验，使用合成的促性腺激素释放因子类似物（GnRH，100微克，静脉注射）。所有患者的促黄体生成素（LH）血浆水平均一致偏低，而促卵泡生成素（FSH）和性类固醇的血浆水平在一些患者中降低程度较小，在另一些患者中则处于正常范围。在所有患者中，GnRH类似物刺激导致LH水平显著升高，但FSH反应则不那么明显，且未显著超过正常对照组。我们的研究结果表明TS患者促性腺激素释放减少，并支持下丘脑参与该疾病的假说。
