Yuan Jingping, Shi Xuehui, Chen Chuang, He Huihua, Liu Lin, Wu Juan, Yan Honglin
Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China.
Oncol Lett. 2019 Sep;18(3):3249-3255. doi: 10.3892/ol.2019.10618. Epub 2019 Jul 15.
CD47 functions as a dominant anti-engulfment signal on tumour cells and is overexpressed in various malignant tumours. However, the expression and functional significance of CD47 in triple-negative breast cancer (TNBC) is not completely understood. In the present study, CD47 was demonstrated to be overexpressed in TNBC solid tumours. Moreover, increased CD47 expression was significantly associated with an advanced tumour-node-metastasis stage, lymph node involvement and recurrence. Moreover, CD47 was an unfavourable and independent prognostic factor for 5-year disease-free survival in patients with TNBC. In addition, the expression of CD47 was associated with several markers of epithelial-mesenchymal transition (EMT). The present study was the first to demonstrate an association between increased expression of CD47 with EMT and poor prognosis of TNBC. Thus, CD47 may be a potential prognostic biomarker and therapeutic target for TNBC.
CD47在肿瘤细胞上作为一种主要的抗吞噬信号发挥作用，且在各种恶性肿瘤中过表达。然而，CD47在三阴性乳腺癌（TNBC）中的表达及功能意义尚未完全明确。在本研究中，CD47在TNBC实体瘤中被证实过表达。此外，CD47表达增加与肿瘤-淋巴结-转移分期进展、淋巴结受累及复发显著相关。而且，CD47是TNBC患者5年无病生存的不良独立预后因素。另外，CD47的表达与上皮-间质转化（EMT）的几种标志物相关。本研究首次证明CD47表达增加与TNBC的EMT及不良预后之间存在关联。因此，CD47可能是TNBC的一种潜在预后生物标志物和治疗靶点。
