McElroy S L, Keck P E, Pope H G, Hudson J I
Epidemiology Laboratory, McLean Hospital, Belmont, Massachusetts 02178.
J Clin Psychopharmacol. 1988 Aug;8(4):275-9.
Six consecutive patients with rapid-cycling bipolar disorder, refractory or only minimally responsive to treatment with lithium salts and neuroleptics, including five also refractory to carbamazepine, all demonstrated a moderate or marked response to the anticonvulsant valproate. These observations suggest that valproate may represent a promising treatment alternative in this often treatment-resistant form of bipolar disorder.
连续六例快速循环型双相情感障碍患者，对锂盐和抗精神病药物治疗无效或仅有轻微反应，其中五例对卡马西平也无效，所有患者均对抗惊厥药丙戊酸盐有中度或显著反应。这些观察结果表明，丙戊酸盐可能是这种常具治疗抵抗性的双相情感障碍的一种有前景的治疗选择。
