Toprak Murat, Erden Metin, Alpaycı Mahmut, Ediz Levent, Yazmalar Levent, Hız Özcan, Tekeoğlu İbrahim
Department of Physical Medicine and Rehabilitation, Medical Faculty of Yüzüncü Yıl University, Van, Turkey.
Department of Physical Medicine and Rehabilitation, Van Training and Research Hospital, Van, Turkey.
Turk J Phys Med Rehabil. 2017 Jun 3;63(2):160-164. doi: 10.5606/tftrd.2017.291. eCollection 2017 Jun.
This study aims to investigate the scores of depression, anxiety, sleep and quality of life (QoL), to identify the prevalence of fibromyalgia (FM) in Behçet's disease (BD), and to evaluate whether there is a difference between BD patients with and without FM in these scores.
Between March 2008 and January 2009, 97 patients with BD and 95 age- and sex-matched healthy controls were included in the study. The patients with BD were divided into two groups according to the presence or absence of FM. All participants were evaluated by the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburgh Sleep Quality Index (PSQI), and Medical Outcomes Study Short Form-36 (SF-36).
Compared to the controls, FM prevalence was higher (19.6% vs 3.2%) with increased BDI and BAI scores, while the subscores of SF-36 including physical function, physical role, pain, general health, social function, and emotional role decreased in BD patients (for all p<0.001). All BD patients with FM were females (n=19), while only 46% of BD patients without FM were females (n=36) (p<0.001). In BD patients with FM, compared to female BD patients without FM, the mean age (p=0.017), disease duration (p=0.028), and BDI scores (p=0.017) were significantly higher, while the PSQI scores (p=0.001) and SF-36 subscores, except general health (p=0.114), were significantly lower (for all p<0.05).
Our study results suggest that patients with BD have an increased severity of depression and anxiety, higher frequency of FM, and worsened QoL than healthy individuals. In addition, the presence of FM seems to be related with female sex, longer disease duration, older age, depression, sleep disturbance, and poor QoL in BD patients.
本研究旨在调查抑郁、焦虑、睡眠及生活质量（QoL）评分，确定白塞病（BD）中纤维肌痛（FM）的患病率，并评估有FM和无FM的BD患者在这些评分上是否存在差异。
2008年3月至2009年1月，97例BD患者和95例年龄及性别匹配的健康对照者纳入本研究。BD患者根据是否存在FM分为两组。所有参与者均通过贝克抑郁量表（BDI）、贝克焦虑量表（BAI）、匹兹堡睡眠质量指数（PSQI）及医学结局研究简明健康调查量表（SF-36）进行评估。
与对照组相比，BD患者FM患病率更高（19.6%对3.2%），BDI和BAI评分升高，而BD患者SF-36的包括身体功能、身体角色、疼痛、总体健康、社会功能及情感角色等子评分降低（所有p<0.001）。所有有FM的BD患者均为女性（n=19），而无FM的BD患者中仅46%为女性（n=36）（p<0.001）。在有FM的BD患者中，与无FM的女性BD患者相比，平均年龄（p=0.017）、病程（p=0.028）及BDI评分（p=0.017）显著更高，而PSQI评分（p=0.001）及除总体健康外的SF-36子评分（p=0.114）显著更低（所有p<0.05）。
我们的研究结果表明，与健康个体相比，BD患者抑郁和焦虑严重程度增加、FM发生率更高且生活质量更差。此外，FM的存在似乎与BD患者的女性性别、更长病程、更高年龄、抑郁、睡眠障碍及较差生活质量相关。
