Ayar Koray, Metİn Ökmen Burcu, Altan Lale, KÖsegİl ÖztÜrk Esra
Department of Internal Medicine, Division of Rheumatology, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.
Department of Physical Therapy and Rehabilitation, University of Health Sciences, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.
Arch Rheumatol. 2020 Jan 8;35(3):401-408. doi: 10.46497/ArchRheumatol.2020.7729. eCollection 2020 Sep.
This study aims to determine the incidence of fibromyalgia (FM) in female patients with Behçet's disease (BD) and to investigate whether disease activity changes in the presence of FM in female patients with BD.
This cross-sectional study included 72 female patients with BD (mean age 39.7±10.5 years; range, 22 to 74 years) between June 2018 and February 2019. The frequency of FM was evaluated according to the American College of Rheumatology alternative criteria. Active clinical features and BD activity were evaluated with the Behçet's disease activity form (BDCAF).
The prevalence of FM was 29.2% in the BD patients. BD clinical activity index, patients' perceptions of disease activity and clinicians' overall perceptions of disease activity scores were significantly higher in BD patients with FM (p=0.003, p<0.001 and p=0.025, respectively). The active clinical features of BD were not different between the groups except for genital ulcer. The prevalence of active genital ulcers was higher in BD patients with FM than in BD patients without FM (38.1% vs. 13.7%, respectively).
Disease activity is higher in female BD patients with FM than those without FM. High disease activity in female BD patients with FM may be associated with the presence of genital ulcers.
本研究旨在确定白塞病（BD）女性患者中纤维肌痛（FM）的发病率，并调查BD女性患者中存在FM时疾病活动度是否发生变化。
这项横断面研究纳入了2018年6月至2019年2月期间的72例BD女性患者（平均年龄39.7±10.5岁；范围22至74岁）。根据美国风湿病学会替代标准评估FM的发生率。采用白塞病活动表（BDCAF）评估临床活动特征和BD活动度。
BD患者中FM的患病率为29.2%。FM的BD患者的BD临床活动指数、患者对疾病活动度的感知以及临床医生对疾病活动度评分的总体感知均显著更高（分别为p = 0.003、p < 0.001和p = 0.025）。除生殖器溃疡外，两组间BD的临床活动特征无差异。FM的BD患者中活动性生殖器溃疡的患病率高于无FM的BD患者（分别为38.1%和13.7%）。
FM的BD女性患者的疾病活动度高于无FM的患者。FM的BD女性患者的高疾病活动度可能与生殖器溃疡的存在有关。
