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局部应用利福霉素对大鼠硬膜外纤维化的影响。

Effect of topical rifamycin application on epidural fibrosis in rats.

作者信息

Dinç Cem, Tuncer Cengiz, Türkoğlu Mehmet Erhan, Tokmak Mehmet, Ocak Pınar, Er Uygur

机构信息

Department of Neurosurgery, Düzce University School of Medicine, Düzce, Turkey.

Department of Neurosurgery, Ministry of Health, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

出版信息

Turk J Phys Med Rehabil. 2019 Jan 31;65(1):24-29. doi: 10.5606/tftrd.2019.2442. eCollection 2019 Mar.

DOI:10.5606/tftrd.2019.2442

PMID:31453541

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6648180/

Abstract

OBJECTIVES

This study aims to investigate the effects of topical rifamycin SV application on epidural fibrosis formation in a rat model.

MATERIALS AND METHODS

Between March 2015 and April 2015, a total of 20 Wistar rats were equally and randomly divided into laminectomy only group (control group) and laminectomy and rifamycin SV group (treatment group). Laminectomy was performed between L3-L5 in all rats. Surgical field was irrigated with 1 mL rifamycin SV (1 mL). After four weeks, vertebral columns of the rats were removed en bloc between the L1 and L5 levels, and epidural fibrosis and arachnoid involvement were histopathologically evaluated and graded.

RESULTS

Grade 3 epidural fibrosis formation ratio was lower in the treatment group (40%) compared to the control group (80%). However, there was no statistically significant difference between the treatment and control groups in terms of epidural fibrosis (p=0.164) and arachnoid involvement (p=0.303).

CONCLUSION

Intraoperative rifamycin irrigation tends to reduce epidural fibrosis formation risk, although not statistically significant.

摘要

目的

本研究旨在探讨局部应用利福霉素SV对大鼠模型硬膜外纤维化形成的影响。

材料与方法

2015年3月至2015年4月期间，将20只Wistar大鼠平均随机分为单纯椎板切除术组（对照组）和椎板切除术加用利福霉素SV组（治疗组）。所有大鼠均在L3-L5之间进行椎板切除术。手术区域用1 mL利福霉素SV（1 mL）冲洗。四周后，在L1和L5水平之间整块取出大鼠的脊柱，对硬膜外纤维化和蛛网膜受累情况进行组织病理学评估和分级。