Choi Hyu Jin, Kim Kyoung Beom, Kwon Young-Min
Department of Neurosurgery, College of Medicine, Dong-A University, Busan, Korea.
J Korean Neurosurg Soc. 2011 Jun;49(6):323-8. doi: 10.3340/jkns.2011.49.6.323. Epub 2011 Jun 30.
Epidural fibrosis and adhesion are the main reasons for post-laminectomy sustained pain and functional disability. In this study, the authors investigate the effect of irradiated freeze-dried human amniotic membrane on reducing epidural adhesion after laminectomy on a rat model.
A total of 20 rats were divided into two groups. The group A did not receive human amniotic membrane implantation after laminectomy and group B underwent human amniotic membrane implantation after laminectomy. Gross and microscopic findings were evaluated and compared at postoperative 1, 3 and 8 weeks.
The amount of scar tissue and tenacity were reduced grossly in group of rats with human amniotic membrane implantation (group B). On a microscopic evaluation, there were less inflammatory cell infiltration and fibroblast proliferation in group B.
This experimental study shows that implantation of irradiated freeze-dried human amniotic membrane reduce epidural fibrosis and adhesion after spinal laminectomy in a rat model.
硬膜外纤维化和粘连是椎板切除术后持续疼痛和功能障碍的主要原因。在本研究中，作者在大鼠模型上研究辐照冻干人羊膜对减少椎板切除术后硬膜外粘连的作用。
总共20只大鼠被分为两组。A组在椎板切除术后未接受人羊膜植入，B组在椎板切除术后接受人羊膜植入。在术后1周、3周和8周对大体和微观结果进行评估和比较。
植入人羊膜的大鼠组（B组）大体上瘢痕组织量和坚韧度降低。在微观评估中，B组炎症细胞浸润和成纤维细胞增殖较少。
本实验研究表明，在大鼠模型中，植入辐照冻干人羊膜可减少椎板切除术后的硬膜外纤维化和粘连。
