Friedman G, Friedman B
Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel.
Klin Wochenschr. 1988 Dec 1;66(23):1167-70. doi: 10.1007/BF01727663.
Twenty-four patients with biopsy proven temporal arteritis were followed for 7 years and the effect and duration of corticosteroid treatment was evaluated. An initial dose of 35 mg prednisone daily was sufficient to control symptoms and signs in most of the patients. Flare-up rates upon corticosteroid reduction were high, especially in the first 24 months of treatment. Flare-ups were more common (greater than twice) in "non-western" Jews as compared to "western" Jews. Serious corticosteroid side effects were uncommon. Corticosteroid treatment was withdrawn from 7 patients after 5 years; two of these patients suffered flare-ups within 16 months. Nineteen patients remained on prednisone, in an average dose of 4 mg/day, 7 years after diagnosis. Thus, corticosteroid treatment in temporal arteritis should be prolonged in the majority of patients.
对24例经活检证实为颞动脉炎的患者进行了7年的随访，并评估了皮质类固醇治疗的效果和持续时间。大多数患者每日初始剂量35毫克泼尼松足以控制症状和体征。在减少皮质类固醇剂量时复发率很高，尤其是在治疗的最初24个月。与“西方”犹太人相比，“非西方”犹太人的复发更为常见（超过两次）。严重的皮质类固醇副作用并不常见。7例患者在5年后停用皮质类固醇治疗；其中2例患者在16个月内复发。诊断7年后，19例患者仍在服用泼尼松，平均剂量为每日4毫克。因此，大多数颞动脉炎患者的皮质类固醇治疗应延长。
