State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Chem Commun (Camb). 2019 Sep 10;55(73):10976-10979. doi: 10.1039/c9cc05832j.
An unprecedented sequential [3+3]/[3+3] annulation of allenoates and dienes catalyzed by phosphine has been developed, which provides novel and facile access to highly functionalized hydroisoquinoline derivatives. The reaction features a wide reaction scope and mild reaction conditions. δ-sulfonamido-allenoates, acting as a five-atom unit, represent a new synthon in the reactions of allenoates.
膦催化的烯丙酸盐和二烯的前所未有的串联[3+3]/[3+3]环化反应已经被开发出来，为高度官能化的氢化异喹啉衍生物提供了新颖且简便的途径。该反应具有广泛的反应范围和温和的反应条件。δ-磺酰胺基烯丙酸盐作为五原子单元，在烯丙酸盐的反应中代表了一种新的合成子。
