Copper-Catalyzed Diastereoselective 1,2-Difunctionalization of Oxabenzonorbornadienes Leading to β-Thiocyanato Thioethers.
作者信息
Lin Qifu, Yang Wen, Yao Yongqi, Chen Shuqi, Tan Yun, Chen Donghan, Yang Dingqiao
机构信息
Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, College of Chemistry , South China Normal University , Guangzhou 510006 , People's Republic of China.
College of Marine Sciences , Beibu Gulf University , Qinzhou 535011 , People's Republic of China.
出版信息
Org Lett. 2019 Sep 20;21(18):7244-7247. doi: 10.1021/acs.orglett.9b02452. Epub 2019 Aug 27.
A novel copper-catalyzed complete diastereoselective 1,2-difunctionalization of oxabicyclic alkenes has been developed. Two C-S bonds were constructed simultaneously on the oxabenzonorbornadienes leading to β-thiocyanato thioethers through the three-component (oxabicyclic alkenes, aryl iodides, and potassium thiocyanate), one-pot reaction. Various functional groups attached to the substrates were tolerated in this protocol to afford the corresponding β-thiocyanato thioether products in moderate yields.
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