Tiwari Kaushal Kishore, Bevilacqua Stefano, Aquaro Giovanni Donato, Festa Pierluigi, Ait-Ali Lamia, Gasbarri Tommaso, Solinas Marco, Glauber Mattia
College of Medical Sciences Teaching Hospital Department of Cardiothoracic and Vascular Surgery Bharatpur Chitwan Nepal Department of Cardiothoracic and Vascular Surgery, College of Medical Sciences, Teaching Hospital, Bharatpur, Chitwan, Nepal.
Fondazione Toscana Gabriele Monasterio (FTGM) G. Pasquinucci Heart Hospital Department of Adult Cardiac Surgery Massa Italy Fondazione Toscana Gabriele Monasterio (FTGM), G. Pasquinucci Heart Hospital, Department of Adult Cardiac Surgery, Via Aurelia Sud, Massa, Italy.
Braz J Cardiovasc Surg. 2019 Aug 27;34(4):451-457. doi: 10.21470/1678-9741-2018-0406.
To evaluate the aortic wall elasticity using the maximal rate of systolic distension (MRSD) and maximal rate of diastolic recoil (MRDR) and their correlation with the aortic size index (ASI).
Forty-eight patients with thoracic aortic aneurysm were enrolled in this study. A standard magnetic resonance imaging (MRI) protocol was used to calculate MRSD and MRDR. Both MRSD and MRDR were expressed as percentile of maximal area/10-3 sec. ASI (maximal aortic diameter/body surface area) was calculated. A correlation between MRSD, MRDR, ASI, and the patient's age was performed using regression plot.
A significant correlation between MRSD (t=-4,36; r2=0.29; P≤0.0001), MRDR (t=3.92; r2=0.25; P=0.0003), and ASI (25±4.33 mm/m2; range 15,48-35,14 mm/m2) is observed. As ASI increases, aortic MRSD and MRDR decrease. Such inverse correlation between MRSD, MRDR, and ASI indicates increased stiffness of the ascending aorta. A significant correlation between the patient's age and the decrease in MRSD and MRDR is observed.
MRSD and MRDR are significantly correlated with ASI and the patient's age. They seem to describe properly the increasing stiffness of aortas. These two new indexes provide a promising, accessible, and reproducible approach to evaluate the biomechanical property of the aorta.
使用收缩期扩张最大速率（MRSD）和舒张期回缩最大速率（MRDR）评估主动脉壁弹性，并研究它们与主动脉尺寸指数（ASI）的相关性。
本研究纳入了48例胸主动脉瘤患者。采用标准磁共振成像（MRI）方案计算MRSD和MRDR。MRSD和MRDR均表示为最大面积/10 - 3秒的百分比。计算ASI（最大主动脉直径/体表面积）。使用回归图分析MRSD、MRDR、ASI与患者年龄之间的相关性。
观察到MRSD（t = -4.36；r2 = 0.29；P≤0.0001）、MRDR（t = 3.92；r2 = 0.25；P = 0.0003）与ASI（25±4.33 mm/m2；范围15.48 - 35.14 mm/m2）之间存在显著相关性。随着ASI增加，主动脉MRSD和MRDR降低。MRSD、MRDR与ASI之间的这种负相关表明升主动脉僵硬度增加。观察到患者年龄与MRSD和MRDR降低之间存在显著相关性。
MRSD和MRDR与ASI及患者年龄显著相关。它们似乎能恰当地描述主动脉僵硬度的增加。这两个新指标为评估主动脉生物力学特性提供了一种有前景、可及且可重复的方法。
