Department of Zoology, Vidyasagar University, Midnapore 721102, West Bengal, India.
Department of General Medicine, Midnapore Medical College and Hospital, Midnapore, West Bengal 721101, India.
Gene. 2019 Nov 30;719:144071. doi: 10.1016/j.gene.2019.144071. Epub 2019 Aug 24.
RNA interference (RNAi) has extensive potential to revolutionize every aspect of clinical application in biomedical research. One of the promising tools is the Small interfering RNA (siRNA) molecules within a cellular component. Principally, siRNA mediated innovative advances are increasing rapidly in support of cancer diagnosis and therapeutic purposes. Conversely, it has some delivery challenges to the site of action within the cells of a target organ, due to the progress of nucleic acids engineering and advance material science research contributing to the exceptional organ-specific targeted therapy. This siRNA based therapeutic technique definitely favors a unique and effective prospect to cancer patients. Herein, the significant drive also takes to review and summarize the major organ specific targets of diverse siRNAs based gene silencing mechanism. This machinery promisingly served as the inhibitor components for cancer development in the human model. Furthermore, the focus is also given to current applications on siRNA based quantifiable therapy leading to the silencing of cancer related gene expression in a sequence dependent and selective manner for cancer treatment. That might be a potent tool against the traditional chemotherapy techniques. Therefore, the siRNA mediated cancer gene therapy definitely require sharp attention like future weapons in opposition to cancer by the method of non-invasive siRNA delivery and effective gene silencing approaches.
RNA 干扰 (RNAi) 具有广泛的潜力，可以彻底改变生物医学研究中临床应用的各个方面。有前途的工具之一是细胞成分内的小干扰 RNA (siRNA) 分子。主要是，siRNA 介导的创新进展迅速增加，以支持癌症诊断和治疗目的。然而，由于核酸工程的进展和先进材料科学研究为特殊的靶向器官治疗做出了贡献，它在向靶器官细胞内的作用部位传递方面存在一些挑战。这种基于 siRNA 的治疗技术肯定对癌症患者具有独特而有效的前景。在此，重大动力还在于回顾和总结基于不同 siRNA 的基因沉默机制的主要器官特异性靶标。该机制有望成为人类模型中癌症发展的抑制剂成分。此外，重点还在于基于 siRNA 的可量化治疗的当前应用，该治疗以序列依赖性和选择性方式沉默癌症相关基因表达，用于癌症治疗。这可能是对抗传统化疗技术的有力工具。因此，siRNA 介导的癌症基因治疗肯定需要像未来对抗癌症的武器一样引起关注，通过非侵入性的 siRNA 传递和有效的基因沉默方法。
