Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Josef Stelzmann Street 24, 50937 Cologne, Germany.
Int J Mol Sci. 2019 Aug 26;20(17):4158. doi: 10.3390/ijms20174158.
Tumor metabolism and its specific alterations have become an integral part of understanding functional alterations leading to malignant transformation and maintaining cancer progression. Here, we review the metabolic changes in B-cell neoplasia, focusing on the effects of tumor metabolism on the tumor microenvironment (TME). Particularly, innate and adaptive immune responses are regulated by metabolites in the TME such as lactate. With steadily increasing therapeutic options implicating or utilizing the TME, it has become essential to address the metabolic alterations in B-cell malignancy for therapeutic approaches. In this review, we discuss metabolic alterations of B-cell lymphoma, consequences for currently used therapy regimens, and novel approaches specifically targeting metabolism in the TME.
肿瘤代谢及其特定改变已成为理解导致恶性转化和维持癌症进展的功能改变的一个组成部分。在这里，我们回顾了 B 细胞肿瘤发生中的代谢变化，重点讨论了肿瘤代谢对肿瘤微环境（TME）的影响。特别是，TME 中的代谢物，如乳酸盐，调节先天和适应性免疫反应。随着越来越多的治疗选择涉及或利用 TME，解决 B 细胞恶性肿瘤中的代谢改变对于治疗方法变得至关重要。在这篇综述中，我们讨论了 B 细胞淋巴瘤的代谢改变、对当前治疗方案的影响以及专门针对 TME 代谢的新方法。
