• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

两种多肉植物精油对多药耐药白血病细胞的抗肿瘤机制

Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell.

作者信息

Poma Paola, Labbozzetta Manuela, McCubrey James A, Ramarosandratana Aro Vonjy, Sajeva Maurizio, Zito Pietro, Notarbartolo Monica

机构信息

Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90128 Palermo, Italy.

Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.

出版信息

Pharmaceuticals (Basel). 2019 Aug 26;12(3):124. doi: 10.3390/ph12030124.

DOI:10.3390/ph12030124
PMID:31454963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6789815/
Abstract

Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of obtained by hydrodistillation and compared the chemical composition of its essential oil with that of . Our results demonstrated the anticancer and proapoptotic activities of both species against acute myeloid leukemia on an in vitro model and its multidrug resistant variant involving NF-κB pathway. The essential oils of both species produced a significant decrease in many targets of NF-κB both at mRNA and protein levels. The results corroborate the idea that essential oils may be a good alternative to traditional drugs in the treatment of cancer, especially in drug resistant cancer.

摘要

耐药性仍然是癌症治疗中的一个主要挑战。耐药性决定因素的多样性引发了关于应对这些因素的最佳策略的问题。精油显示出可抑制不同类型肿瘤细胞的生长。精油包含几类化学化合物，其活性部分的异质性有助于防止耐药性的产生。在本文中，我们通过气相色谱 - 质谱法分析了通过水蒸馏获得的[植物名称]叶片精油的化学成分，并将其精油的化学成分与[另一植物名称]的进行了比较。我们的结果表明，这两个物种的精油在体外模型中对急性髓性白血病及其涉及NF-κB途径的多药耐药变体均具有抗癌和促凋亡活性。这两个物种的精油在mRNA和蛋白质水平上均使NF-κB的许多靶点显著降低。这些结果证实了精油在癌症治疗中，尤其是在耐药性癌症治疗中，可能是传统药物的良好替代品这一观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/bc5c29fc5de1/pharmaceuticals-12-00124-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/1ed910044fd0/pharmaceuticals-12-00124-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/787204789880/pharmaceuticals-12-00124-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/fcb0a1e2d58d/pharmaceuticals-12-00124-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/909aab0372ce/pharmaceuticals-12-00124-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/87b0b5b0e0a6/pharmaceuticals-12-00124-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/e4de16bc6971/pharmaceuticals-12-00124-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/a3e958dfdce9/pharmaceuticals-12-00124-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/d44e9910ebf9/pharmaceuticals-12-00124-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/bc5c29fc5de1/pharmaceuticals-12-00124-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/1ed910044fd0/pharmaceuticals-12-00124-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/787204789880/pharmaceuticals-12-00124-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/fcb0a1e2d58d/pharmaceuticals-12-00124-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/909aab0372ce/pharmaceuticals-12-00124-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/87b0b5b0e0a6/pharmaceuticals-12-00124-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/e4de16bc6971/pharmaceuticals-12-00124-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/a3e958dfdce9/pharmaceuticals-12-00124-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/d44e9910ebf9/pharmaceuticals-12-00124-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acd9/6789815/bc5c29fc5de1/pharmaceuticals-12-00124-g009.jpg

相似文献

1
Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell.两种多肉植物精油对多药耐药白血病细胞的抗肿瘤机制
Pharmaceuticals (Basel). 2019 Aug 26;12(3):124. doi: 10.3390/ph12030124.
2
Essential oil of Cyphostemma juttae (Vitaceae): Chemical composition and antitumor mechanism in triple negative breast cancer cells.嘉宝果（葡萄科）精油：化学成分及对三阴性乳腺癌细胞的抗肿瘤机制。
PLoS One. 2019 Mar 28;14(3):e0214594. doi: 10.1371/journal.pone.0214594. eCollection 2019.
3
Essential Oil Composition of and in Vitro Biological Activity on Two Drug-Resistant Models.和在两种耐药模型中的体外生物活性的精油成分。
Molecules. 2019 Aug 7;24(16):2871. doi: 10.3390/molecules24162871.
4
In Vitro Modulation of P-Glycoprotein Activity by Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R.精油对急性髓系白血病细胞系HL-60R中P-糖蛋白活性的体外调节作用
Pharmaceuticals (Basel). 2021 Jan 31;14(2):111. doi: 10.3390/ph14020111.
5
Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas.奥罗勒（Ocimum basilicum L.）和阿尔及利亚撒哈拉阿特拉斯（Thymus algeriensis Boiss. & Reut.）的精油和乙醇提取物的化学成分和生物活性。
BMC Complement Altern Med. 2019 Jun 21;19(1):146. doi: 10.1186/s12906-019-2556-y.
6
Chemical composition, in vitro antioxidant and anti-inflammatory properties of essential oils of four dietary and medicinal plants from Cameroon.喀麦隆四种食用和药用植物精油的化学成分、体外抗氧化和抗炎特性
BMC Complement Altern Med. 2016 Apr 7;16:117. doi: 10.1186/s12906-016-1096-y.
7
Chemical composition, in vitro antitumor and pro-oxidant activities of Glandora rosmarinifolia (Boraginaceae) essential oil.迷果芹挥发油的化学成分、体外抗肿瘤及促氧化活性。
PLoS One. 2018 May 3;13(5):e0196947. doi: 10.1371/journal.pone.0196947. eCollection 2018.
8
Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression.筋骨草中挥发油萜类成分通过抑制 IκBα 激酶、NF-κB 激活下调、促进凋亡和抑制 NF-κB 调控基因表达而发挥抗炎和抗癌作用。
Biomed Pharmacother. 2017 Nov;95:1876-1885. doi: 10.1016/j.biopha.2017.09.115. Epub 2017 Oct 6.
9
A chemometric assessment of essential oil variation of three Salvia species indigenous to South Africa.三种南非特有鼠尾草属植物精油变异性的化学计量学评价。
Phytochemistry. 2020 Apr;172:112249. doi: 10.1016/j.phytochem.2019.112249. Epub 2020 Jan 17.
10
Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants.黎巴嫩药用植物精油的植物化学成分分析及其对多药耐药白血病细胞的细胞毒性。
Planta Med. 2012 Dec;78(18):1927-31. doi: 10.1055/s-0032-1327896. Epub 2012 Nov 15.

引用本文的文献

1
Biological Activities and Chemical Profiles of Extracts.提取物的生物活性和化学特征
Plants (Basel). 2023 May 10;12(10):1943. doi: 10.3390/plants12101943.
2
Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia.急性髓系白血病中 P-糖蛋白的天然抑制剂。
Int J Mol Sci. 2023 Feb 18;24(4):4140. doi: 10.3390/ijms24044140.
3
Progress and challenges of multidrug resistance proteins in diseases.多药耐药蛋白在疾病中的研究进展与挑战

本文引用的文献

1
Essential Oil Composition of and in Vitro Biological Activity on Two Drug-Resistant Models.和在两种耐药模型中的体外生物活性的精油成分。
Molecules. 2019 Aug 7;24(16):2871. doi: 10.3390/molecules24162871.
2
Cytotoxicity of oleanolic and ursolic acid derivatives toward hepatocellular carcinoma and evaluation of NF-κB involvement.齐墩果酸和熊果酸衍生物对肝癌细胞的细胞毒性及对 NF-κB 作用的评价。
Bioorg Chem. 2019 Sep;90:103054. doi: 10.1016/j.bioorg.2019.103054. Epub 2019 Jun 7.
3
Novel Targeted Nano-Parthenolide Molecule against NF-kB in Acute Myeloid Leukemia.
Am J Cancer Res. 2022 Oct 15;12(10):4483-4501. eCollection 2022.
4
Potential of as a Cancer Treatment Adjuvant and an Epigenetic Regulator.作为癌症治疗佐剂和表观遗传调节剂的潜力。
Molecules. 2022 Sep 29;27(19):6425. doi: 10.3390/molecules27196425.
5
Antitumor Effect of (Boraginaceae) Essential Oil through Inhibition of the Activity of the Topo II Enzyme in Acute Myeloid Leukemia.白花丹科精油通过抑制拓扑异构酶 II 酶活性对急性髓细胞白血病的抗肿瘤作用。
Molecules. 2022 Jun 29;27(13):4203. doi: 10.3390/molecules27134203.
6
A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update.萜类精油的抗肿瘤活性的叙述性综述：更新。
Biomed Res Int. 2022 May 24;2022:6317201. doi: 10.1155/2022/6317201. eCollection 2022.
7
In Vitro Modulation of P-Glycoprotein Activity by Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R.精油对急性髓系白血病细胞系HL-60R中P-糖蛋白活性的体外调节作用
Pharmaceuticals (Basel). 2021 Jan 31;14(2):111. doi: 10.3390/ph14020111.
8
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View.NF-κB 能否被视为肿瘤疾病的有效药物靶点？我们的观点。
Int J Mol Sci. 2020 Apr 27;21(9):3070. doi: 10.3390/ijms21093070.
9
Essential Oil from Pinecones Inhibits Gastric Cancer Cells via the HIPPO/YAP Signaling Pathway.松果精油通过 Hippo/YAP 信号通路抑制胃癌细胞。
Molecules. 2019 Oct 25;24(21):3851. doi: 10.3390/molecules24213851.
新型靶向纳米鬼臼脂素分子抑制 NF-κB 在急性髓系白血病中的作用。
Molecules. 2019 Jun 3;24(11):2103. doi: 10.3390/molecules24112103.
4
MicroRNA-125a regulates proliferation and apoptosis of acute myeloid leukemia through targeting NF-κB pathway.MicroRNA-125a 通过靶向 NF-κB 通路调节急性髓系白血病的增殖和凋亡。
Eur Rev Med Pharmacol Sci. 2019 May;23(9):3594-3601. doi: 10.26355/eurrev_201905_17781.
5
Inhibitor of apoptosis proteins in human health and disease.凋亡蛋白抑制因子在人类健康与疾病中的作用
Genes Immun. 2019 Nov;20(8):641-650. doi: 10.1038/s41435-019-0078-8. Epub 2019 May 21.
6
Imaging Flow Cytometric Analysis of Stilbene-Dependent Apoptosis in Drug Resistant Human Leukemic Cell Lines.基于芪类化合物的耐药性人白血病细胞系凋亡的流式细胞术分析。
Molecules. 2019 May 17;24(10):1896. doi: 10.3390/molecules24101896.
7
Essential oil of Cyphostemma juttae (Vitaceae): Chemical composition and antitumor mechanism in triple negative breast cancer cells.嘉宝果（葡萄科）精油：化学成分及对三阴性乳腺癌细胞的抗肿瘤机制。
PLoS One. 2019 Mar 28;14(3):e0214594. doi: 10.1371/journal.pone.0214594. eCollection 2019.
8
Potential Therapeutic Applications of MDA-9/Syntenin-NF-κB-RKIP Loop in Human Liver Carcinoma.MDA-9/Syntenin-NF-κB-RKIP 环路在人肝癌中的潜在治疗应用。
Curr Mol Med. 2018;18(9):630-639. doi: 10.2174/1566524019666190104105043.
9
Phytol: A review of biomedical activities.植物醇：生物医学活性综述。
Food Chem Toxicol. 2018 Nov;121:82-94. doi: 10.1016/j.fct.2018.08.032. Epub 2018 Aug 18.
10
Chemical composition, in vitro antitumor and pro-oxidant activities of Glandora rosmarinifolia (Boraginaceae) essential oil.迷果芹挥发油的化学成分、体外抗肿瘤及促氧化活性。
PLoS One. 2018 May 3;13(5):e0196947. doi: 10.1371/journal.pone.0196947. eCollection 2018.