Department for Management of Science and Technology Development & Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam.
Flinders University College of Medicine and Public Health, Bedford Park, 5042, Adelaide, Australia.
Food Chem Toxicol. 2018 Nov;121:82-94. doi: 10.1016/j.fct.2018.08.032. Epub 2018 Aug 18.
Phytol (PYT) is a diterpene member of the long-chain unsaturated acyclic alcohols. PYT and some of its derivatives, including phytanic acid (PA), exert a wide range of biological effects. PYT is a valuable essential oil (EO) used as a fragrance and a potential candidate for a broad range of applications in the pharmaceutical and biotechnological industry. There is ample evidence that PA may play a crucial role in the development of pathophysiological states. Focusing on PYT and some of its most relevant derivatives, here we present a systematic review of reported biological activities, along with their underlying mechanism of action. Recent investigations with PYT demonstrated anxiolytic, metabolism-modulating, cytotoxic, antioxidant, autophagy- and apoptosis-inducing, antinociceptive, anti-inflammatory, immune-modulating, and antimicrobial effects. PPARs- and NF-κB-mediated activities are also discussed as mechanisms responsible for some of the bioactivities of PYT. The overall goal of this review is to discuss recent findings pertaining to PYT biological activities and its possible applications.
植物醇（PYT）是一种长链不饱和脂环醇类二萜化合物。PYT 及其部分衍生物，包括植烷酸（PA），具有广泛的生物学效应。PYT 是一种有价值的精油（EO），可用作香料，在制药和生物技术行业具有广泛的应用潜力。有充分的证据表明，PA 可能在病理生理状态的发展中起关键作用。本文聚焦 PYT 及其一些最相关的衍生物，对其报道的生物学活性及其潜在作用机制进行了系统综述。最近的 PYT 研究表明其具有抗焦虑、调节代谢、细胞毒性、抗氧化、自噬和凋亡诱导、镇痛、抗炎、免疫调节和抗菌作用。还讨论了 PPARs 和 NF-κB 介导的活性，作为 PYT 部分生物活性的作用机制。本文的总体目标是讨论与 PYT 生物学活性及其可能应用相关的最新发现。
