Faculdade de Medicina, Universidade Estadual Paulista (UNESP), Botucatu, Brazil.
Instituto de Biociencias, Universidade Estadual Paulista (UNESP), Botucatu, Brazil.
J Matern Fetal Neonatal Med. 2021 Jul;34(14):2235-2239. doi: 10.1080/14767058.2019.1661378. Epub 2019 Sep 11.
Preeclampsia is associated with important vascular maternal changes. However, its repercussions on newborns' circulation have hardly been reported.
To investigate whether early-onset preeclampsia is associated with altered blood flow of the superior mesenteric artery (SMA) in preterm infants.
Prospective study with 60 preterm infants of mothers with early-onset preeclampsia (PE) and 60 of normotensive mothers, paired according to the gestational age, from 2013 to 2016. Maternal, gestational, and neonatal clinical data were evaluated. The outcome of interest was the blood flow velocity in SMA, evaluated by the peak systolic velocity and end-diastolic velocity and by the resistance index and pulsatility index, through the Doppler ultrasound in the first 72 h of life. Covariance analysis was used to determine the PE effect on the SMA blood flow, controlling for possible confounding variables.
The mean gestational age was 30 weeks. Infants of mothers with PE had significantly lower values of peak systolic and end-diastolic velocity (57.75 ± 17.49 and 12.29 ± 5.74) compared with the control group (67.17 ± 29.57 and 15.03 ± 7.52), even after control of covariates.
Early-onset preeclampsia is associated with decreased blood flow of SMA in preterm infants on the first days of life.
子痫前期与母体重要的血管变化有关。然而，其对子代新生儿循环的影响鲜有报道。
研究早发型子痫前期是否与早产儿肠系膜上动脉（SMA）血流改变有关。
这是一项前瞻性研究，纳入了 2013 年至 2016 年间的 60 例早发型子痫前期母亲所生的早产儿和 60 例血压正常母亲所生的早产儿。评估了母亲、妊娠和新生儿的临床数据。研究的结局是通过多普勒超声在出生后 72 小时内评估 SMA 的血流速度，包括收缩期峰值速度和舒张末期速度，以及阻力指数和搏动指数。协方差分析用于确定 PE 对 SMA 血流的影响，同时控制可能的混杂变量。
平均胎龄为 30 周。PE 母亲的婴儿收缩期峰值速度和舒张末期速度明显低于对照组（分别为 57.75 ± 17.49 和 12.29 ± 5.74），即使在控制了混杂变量后也是如此。
早发型子痫前期与早产儿出生后最初几天 SMA 血流减少有关。
