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自噬画作:艺术与科学的前沿交汇

Autophagic paintings: In the frontier of art and science.

机构信息

Fundación Instituto Leloir and IIBBA, CONICET , Buenos Aires , Argentina.

Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Buenos Aires , Argentina.

出版信息

Autophagy. 2019 Nov;15(11):2022-2027. doi: 10.1080/15548627.2019.1659618. Epub 2019 Aug 27.

DOI:10.1080/15548627.2019.1659618
PMID:31455131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6844529/
Abstract

As a PhD student I explored macroautophagy/autophagy induced by starvation in using different microscopy techniques. The beauty and complexity of this process impressed me so deeply that I felt the need to paint it. Thus, I made 2 oil paintings based on my own scientific work, representing the autophagy mechanism at different scales with diverse artistic resources. The first painting, called , is inspired by fluorescence confocal microscopy images. Therefore, saturated colors predominate in the composition. The second one is an oil on canvas titled which reflects autophagy at a smaller scale. This painting depicts this process as revealed by transmission electron microscopy, employing mainly a gray scale of colors. I performed these works with the intention to catch the essence of this biological process, conveying scientific ideas through art. My paintings are not intended only for the scientific community but also for the general public, as an instrument of enjoyment and popularization of science.

摘要

作为一名博士生,我使用不同的显微镜技术研究了饥饿诱导的细胞自噬/巨自噬。这个过程的美妙和复杂性给我留下了深刻的印象,以至于我觉得有必要把它画下来。因此,我根据自己的科学工作创作了两幅油画,用不同的艺术资源代表了不同尺度的自噬机制。第一幅画名为《自噬》,灵感来自荧光共聚焦显微镜图像。因此,构图中主要使用了饱和色。第二幅画名为《自噬的小世界》,画的是较小尺度的自噬。这幅画描绘了电镜下观察到的自噬过程,主要使用了灰度色调。我创作这些作品是为了捕捉这个生物过程的本质,通过艺术传达科学思想。我的画不仅是为科学界准备的,也是为公众准备的,是一种享受和普及科学的工具。

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本文引用的文献

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Zonda is a novel early component of the autophagy pathway in .宗达蛋白是自噬途径中一种新的早期成分。 (注:原文中“in.”表述不完整,这里是根据合理推测补充完整后翻译的,若有更准确原文信息可进一步完善。)
Mol Biol Cell. 2017 Nov 1;28(22):3070-3081. doi: 10.1091/mbc.E16-11-0767. Epub 2017 Sep 13.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).自噬监测检测方法的使用与解读指南(第3版)
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When bigger is better: the role of polyploidy in organogenesis.当越大越好:多倍体在器官发生中的作用。
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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum.自噬体由富含磷脂酰肌醇3-磷酸且与内质网动态相连的膜性区室形成。
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Autophagy fights disease through cellular self-digestion.自噬通过细胞自我消化来对抗疾病。
Nature. 2008 Feb 28;451(7182):1069-75. doi: 10.1038/nature06639.
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Maturation of autophagic vacuoles in Mammalian cells.哺乳动物细胞中自噬泡的成熟
Autophagy. 2005 Apr;1(1):1-10. doi: 10.4161/auto.1.1.1270. Epub 2005 Apr 28.