Hutson P H, Donohoe T P, Curzon G
Department of Neurochemistry, Institute of Neurology, London, UK.
Psychopharmacology (Berl). 1988;95(4):550-2. doi: 10.1007/BF00172974.
The 5-HT1B agonist RU24969 when given either systemically (1 mg/kg SC) or by infusion (0.5, 1.0, 2.0 micrograms) into the region of the paraventricular nucleus of the hypothalamus caused dose-dependent hypophagia in rats previously deprived of food for 18 h. Similar results were obtained at the above dosages of 1-[3-(trifluoromethyl) phenyl] piperazine (TFMPP), which acts on 5-HT1B and possibly also on 5-HT1C receptors. Neither drug significantly affected locomotion following central administration. Food intake was significantly decreased when the 5-HT1A agonist 8-OH-DPAT was given systemically (1 mg/kg SC) to rats previously deprived of food but was unaffected when 8-OH-DPAT (1 microgram) was infused into the paraventricular nucleus of both food-deprived and free feeding rats. Therefore, hypophagia occurs when hypothalamic 5-HT1B (and possibly 5-HT1C) but not 5-HT1A receptors are activated.
5-羟色胺1B（5-HT1B）激动剂RU24969，无论是全身给药（1毫克/千克皮下注射）还是向下丘脑室旁核区域注射（0.5、1.0、2.0微克），都会使先前禁食18小时的大鼠出现剂量依赖性摄食减少。1-[3-（三氟甲基）苯基]哌嗪（TFMPP）以上述剂量给药时也得到了类似结果，该药物作用于5-HT1B受体，也可能作用于5-HT1C受体。中枢给药后，这两种药物均未对运动产生显著影响。给先前禁食的大鼠全身注射（1毫克/千克皮下注射）5-羟色胺1A（5-HT1A）激动剂8-羟基二丙基氨基四氢吡啶（8-OH-DPAT）时，食物摄入量显著减少，但向禁食和自由进食大鼠的室旁核注射8-OH-DPAT（1微克）时，食物摄入量未受影响。因此，当下丘脑5-HT1B（可能还有5-HT1C）而非5-HT1A受体被激活时，会出现摄食减少。
