Walsh A E, Smith K A, Oldman A D, Williams C, Goodall E M, Cowen P J
Psychopharmacology Research Unit, Littlemore Hospital, Oxford, UK.
Psychopharmacology (Berl). 1994 Sep;116(1):120-2. doi: 10.1007/BF02244883.
We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused significant increases in ratings of nausea and light-headedness, though these effects had remitted by the time of the test meal. The results suggest that activation of brain 5-HT2C receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mCPP in the present study could be a consequence of its adverse subjective side effects.
我们采用双盲安慰剂对照设计，研究了5-羟色胺（5-HT）受体激动剂间氯苯哌嗪（mCPP，0.4毫克/千克）对12名健康女性志愿者食物摄入量的影响。与安慰剂相比，mCPP在试餐中显著降低了食物摄入量。mCPP治疗还导致恶心和头晕评分显著增加，不过在试餐时这些影响已经消退。结果表明，激活大脑5-HT2C受体可能会降低人类的食物摄入量；然而，本研究中mCPP的食欲减退作用也可能是其不良主观副作用的结果。
