Children's University Hospital of Basel, Spitalstrasse 33, 4056, Basel, Switzerland.
Children's Hospital of Aarau, Aarau, Switzerland.
BMC Pediatr. 2019 Aug 27;19(1):297. doi: 10.1186/s12887-019-1680-7.
Evidence is growing that both short- and long-term physical exercise have the potential to positively impact on the physiological system related to inflammatory indices, though, such patterns are unknown for pediatric patients with Inflammatory Bowel Disease (IBD). The aim of the present intervention study was to investigate the influence of a single bout and chronic moderate-intensity exercise on IBD-related inflammatory indices and exercise capacity among pediatric individuals with IBD and healthy controls.
Twenty-one pediatric patients with IBD, split into a "remission-group" (IBD-RE; n = 14) and an "active disease group" (IBD-AD; n = 7), were compared to 23 age matched healthy controls (HC). All participants completed a single bout of exercise at baseline and an 8-week exercise intervention. Before and after the single bout of exercise IBD-related inflammatory indices (erythrocyte sedimentation rate (ESR), albumin, C-reactive protein (CRP), cortisol, hemoglobin, hematocrit, thrombocytes and leukocytes) were assessed.
At baseline, after a single bout of exercise, inflammation (albumin, hemoglobin, erythrocytes, hematocrit and leukocytes) increased in all three groups IBD-AD, IBD-RE and HC. CRP and thrombocytes were only elevated in IBD-AD and IBD-RE, compared to HC. After a longer-term exercise intervention, ESR, CRP and thrombocytes significantly decreased in all groups. The longer-term exercise intervention did not decrease acute immunopathologic responses after a single bout of exercise, compared to baseline.
Whereas a single bout of exercise increases albumin, erythrocytes and leukocytes, longer-term moderate-intensity exercise reduced inflammatory markers in pediatric patients with IBD. Children and teenagers with IBD should be encouraged to engage in regular moderate-intensity exercise activities, as such activities may contribute to inflammation suppression and improved disease management.
越来越多的证据表明，短期和长期的体育锻炼都有可能对与炎症指标相关的生理系统产生积极影响，但儿科炎症性肠病 (IBD) 患者的这种模式尚不清楚。本干预研究的目的是调查单次运动和慢性中等强度运动对儿科 IBD 患者和健康对照者的 IBD 相关炎症指标和运动能力的影响。
将 21 名儿科 IBD 患者分为“缓解组”（IBD-RE；n=14）和“活动疾病组”（IBD-AD；n=7），并与 23 名年龄匹配的健康对照组（HC）进行比较。所有参与者在基线时完成一次运动，然后进行 8 周的运动干预。在单次运动前后，评估与 IBD 相关的炎症指标（红细胞沉降率 (ESR)、白蛋白、C 反应蛋白 (CRP)、皮质醇、血红蛋白、红细胞压积、血小板和白细胞）。
在基线时，单次运动后，所有三组（IBD-AD、IBD-RE 和 HC）的炎症标志物（白蛋白、血红蛋白、红细胞、红细胞压积和白细胞）均增加。CRP 和血小板仅在 IBD-AD 和 IBD-RE 中升高，与 HC 相比。经过更长时间的运动干预，所有组的 ESR、CRP 和血小板均显著下降。与基线相比，较长时间的运动干预并没有降低单次运动后的急性免疫病理反应。
单次运动增加白蛋白、红细胞和白细胞，而长期中等强度运动可降低儿科 IBD 患者的炎症标志物。应鼓励患有 IBD 的儿童和青少年定期进行适度的运动活动，因为这些活动可能有助于抑制炎症和改善疾病管理。
