Department of Neurosurgery, Fuzhou 900 Hospital, Fujian Medical University, No.156 Xihuanbei Road, Fuzhou, 350025, People's Republic of China.
Department of Neurosurgery, Fujian provincial Hospital, Chinese People's Armed Police Forces, Fuzhou, 350025, People's Republic of China.
BMC Endocr Disord. 2019 Aug 27;19(1):90. doi: 10.1186/s12902-019-0418-8.
Endothelial cell-specific molecule-1 (ESM-1) is a biomarker associated with tumor progression in pituitary adenoma. We specifically focused on one type of pituitary adenoma, namely null cell adenoma (NCA) and evaluated the relationship between invasion and ESM-1 expression in both vascular endothelial and adenoma tissues.
Tissue samples from 94 patients with pituitary NCA were obtained through microscopic transsphenoidal resection. Tumor size and invasion were determined through preoperative magnetic resonance imaging. Immunohistochemical staining was performed to detect ESM-1 expression. ESM-1 index of ≥3 was defined as high expression.
Signs of invasion were observed in 46 (47.9%) of the 94 patients. Significant differences were observed in the invasion state and maximum tumor diameter between high and low expression of ESM-1 in vascular endothelial tissues (both P < 0.05). Significant positive associations were noted between ESM-1 expression in vascular endothelial tissues and tumor invasion (P = 0.002) and tumor size (P = 0.020). However, only tumor size was associated with ESM-1 expression in adenoma tissues (P = 0.016).
In NCA, a significant positive association between tumor invasion and ESM-1 expression was observed only in vascular endothelial tissues, suggesting that tumor progression occurs mainly through ESM-1-associated mechanism.
内皮细胞特异性分子-1（ESM-1）是与垂体腺瘤肿瘤进展相关的生物标志物。我们特别关注一种垂体腺瘤，即无功能细胞腺瘤（NCA），并评估了血管内皮和腺瘤组织中侵袭与 ESM-1 表达之间的关系。
通过显微镜经蝶窦切除术获得 94 例 NCA 患者的组织样本。通过术前磁共振成像确定肿瘤大小和侵袭程度。进行免疫组织化学染色以检测 ESM-1 表达。ESM-1 指数≥3 定义为高表达。
在 94 例患者中，有 46 例（47.9%）存在侵袭迹象。在血管内皮组织中，ESM-1 的高表达与低表达之间，侵袭状态和最大肿瘤直径存在显著差异（均 P<0.05）。血管内皮组织中 ESM-1 的表达与肿瘤侵袭（P=0.002）和肿瘤大小（P=0.020）呈显著正相关。然而，只有在腺瘤组织中，肿瘤大小与 ESM-1 的表达相关（P=0.016）。
在 NCA 中，仅在血管内皮组织中观察到肿瘤侵袭与 ESM-1 表达之间存在显著正相关，这表明肿瘤进展主要通过 ESM-1 相关机制发生。
