Copenhagen Research Center for Mental Health - CORE, Copenhagen Mental Health Centre , Copenhagen , Denmark.
Regional Centre for Clinical Research in Psychosis, Division of Psychiatry, Stavanger University Hospital , Stavanger , Norway.
Int Rev Psychiatry. 2019 Aug-Sep;31(5-6):413-424. doi: 10.1080/09540261.2019.1643703. Epub 2019 Aug 28.
The last 20 years have seen an increased focus on early intervention in psychotic disorders in research and clinical practice. Interventions have typically aimed at either reducing the duration of untreated psychosis (DUP), or developing specialized treatment facilities for patients with first episode psychosis (FEP). This review presents an overview of the most important trials and meta-analytic evidence within this field. The possibilities for reducing DUP and elements included in specialized early intervention treatment are discussed. Further, it examines long-term outcomes of early interventions and results from prolonged early intervention trials. Lastly, it analyses possible interactions between DUP and specialized early intervention treatment. In conclusion, both elements appear necessary in order to develop an integrated service that can provide the optimal treatment for patients with FEP. The aim of this article is to provide an overview over the most important trials and evidence regarding the outcome of early intervention in first episode psychosis.
过去 20 年来，研究和临床实践越来越关注精神病性障碍的早期干预。干预措施通常旨在缩短未经治疗的精神病（DUP）持续时间，或为首发精神病（FEP）患者建立专门的治疗设施。本综述介绍了该领域最重要的试验和荟萃分析证据。讨论了减少 DUP 的可能性以及专门早期干预治疗中包含的元素。此外，它还检查了早期干预的长期结果以及延长早期干预试验的结果。最后，分析了 DUP 和专门早期干预治疗之间可能存在的相互作用。总之，为了开发能够为 FEP 患者提供最佳治疗的综合服务，这两个因素似乎都是必要的。本文旨在提供关于首发精神病早期干预结果的最重要试验和证据的概述。
