Najberg Mathie, Haji Mansor Muhammad, Boury Frank, Alvarez-Lorenzo Carmen, Garcion Emmanuel
CRCINA, INSERM, Université de Nantes, Université d'Angers, Angers, France.
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R + D Pharma Group (GI-1645), Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Front Pharmacol. 2019 Aug 12;10:887. doi: 10.3389/fphar.2019.00887. eCollection 2019.
Despite the tremendous progress made in the field of cancer therapy in recent years, certain solid tumors still cannot be successfully treated. Alongside classical treatments in the form of chemotherapy and/or radiotherapy, targeted treatments such as immunotherapy that cause fewer side effects emerge as new options in the clinics. However, these alternative treatments may not be useful for treating all types of cancers, especially for killing infiltrative and circulating tumor cells (CTCs). Recent advances pursue the trapping of these cancer cells within a confined area to facilitate their removal for therapeutic and diagnostic purposes. A good understanding of the mechanisms behind tumor cell migration may drive the design of traps that mimic natural tumor niches and guide the movement of the cancer cells. To bring this trapping idea into reality, strong efforts are being made to create structured materials that imitate myelinated fibers, blood vessels, or pre-metastatic niches and incorporate chemical cues such as chemoattractants or adhesive proteins. In this review, the different strategies used (or could be used) to trap tumor cells are described, and relevant examples of their performance are analyzed.
尽管近年来癌症治疗领域取得了巨大进展，但某些实体瘤仍无法得到成功治疗。除了化疗和/或放疗等传统治疗方法外，副作用较小的靶向治疗如免疫疗法在临床上成为新的选择。然而，这些替代治疗方法可能并非对所有类型的癌症都有用，尤其是对于杀死浸润性和循环肿瘤细胞（CTC）。最近的进展致力于将这些癌细胞捕获在一个受限区域内，以便于出于治疗和诊断目的将其清除。深入了解肿瘤细胞迁移背后的机制可能会推动模仿天然肿瘤微环境并引导癌细胞移动的陷阱的设计。为了将这种捕获想法变为现实，人们正在大力努力制造模仿有髓纤维、血管或转移前微环境的结构化材料，并纳入化学信号，如化学引诱剂或粘附蛋白。在这篇综述中，描述了用于（或可用于）捕获肿瘤细胞的不同策略，并分析了它们性能的相关实例。
