Velez Erik M, Desai Bhushan, Jadvar Hossein
Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, 2250 Alcazar St., CSC 102, Los Angeles, CA 90033 USA.
Nucl Med Mol Imaging. 2019 Aug;53(4):247-252. doi: 10.1007/s13139-019-00601-1. Epub 2019 Jun 24.
To determine the utility of F-sodium fluoride positron emission tomography-computed tomography (F-NaF PET/CT) in the imaging assessment of therapy response in men with osseous-only metastatic prostate cancer.
In this Institutional Review Board-approved single institution retrospective investigation, we evaluated 21 F-NaF PET/CT scans performed in 14 patients with osseous metastatic disease from prostate cancer and no evidence of locally recurrent or soft-tissue metastatic disease who received chemohormonal therapy. Imaging-based qualitative and semi-quantitative parameters were defined and compared with changes in serum PSA level.
Qualitative and semi-quantitative image-based assessments demonstrated > 80% concordance with good correlation (SUVmax = 0.71, SUVavg = 0.62, SUVsum = 0.62). Moderate correlation ( = 0.43) was found between SUVmax and PSA-based treatment response assessments. There was no statistically significant correlation between PSA-based disease progression and semi-quantitative parameters. Qualitative imaging assessment was moderately correlated ( = 0.52) with PSA in distinguishing responders and non-responders.
F-NaF PET/CT is complementary to biochemical monitoring in patients with bone-only metastases from prostate cancer which can be helpful in subsequent treatment management decisions.
确定氟-氟化钠正电子发射断层扫描-计算机断层扫描（F-NaF PET/CT）在仅发生骨转移的前列腺癌男性患者治疗反应成像评估中的效用。
在这项经机构审查委员会批准的单机构回顾性研究中，我们评估了14例前列腺癌骨转移患者且无局部复发或软组织转移证据的患者所进行的21次F-NaF PET/CT扫描，这些患者接受了化学激素治疗。定义了基于成像的定性和半定量参数，并与血清PSA水平的变化进行比较。
基于定性和半定量图像的评估显示一致性>80%，相关性良好（SUVmax = 0.71，SUVavg = 0.62，SUVsum = 0.62）。在SUVmax与基于PSA的治疗反应评估之间发现中度相关性（= 0.43）。基于PSA的疾病进展与半定量参数之间无统计学显著相关性。定性成像评估在区分反应者和无反应者方面与PSA中度相关（= 0.52）。
F-NaF PET/CT对仅发生前列腺癌骨转移的患者的生化监测具有补充作用，这有助于后续治疗管理决策。
