Choi Woo June
School of Electrical and Electronics Engineering, College of ICT Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974 Republic of Korea.
Biomed Eng Lett. 2019 Jul 2;9(3):311-325. doi: 10.1007/s13534-019-00118-8. eCollection 2019 Aug.
Preclinical neuroimaging allows for the assessment of brain anatomy, connectivity, and function in laboratory animals, such as mice and this imaging field has been a rapidly growing aimed at bridging the translation gap between animal and human research. The progress in the animal research could be accelerated by high-resolution in vivo optical imaging technologies. Optical coherence tomography-based angiography (OCTA) estimates the scattering from moving red blood cells, providing the visualization of functional micro-vessel networks within tissue beds in vivo without a need for exogenous contrast agents. Recent advancement of OCTA methods have expanded its application to neuroimaging of small animal models of brain disorders. In this paper, we overview the recent development of OCTA techniques for blood flow imaging and its preclinical applications in neuroimaging. In specific, a summary of preclinical OCTA studies for traumatic brain injury, cerebral stroke, and aging brain on mice is reviewed.
临床前神经成像能够对实验动物（如小鼠）的脑解剖结构、连通性和功能进行评估，并且这个成像领域一直在迅速发展，旨在弥合动物研究与人体研究之间的转化差距。高分辨率的体内光学成像技术可以加速动物研究的进展。基于光学相干断层扫描的血管造影（OCTA）通过估算移动红细胞的散射情况，无需外源性造影剂即可在体内可视化组织床内的功能性微血管网络。OCTA方法的最新进展已将其应用扩展到脑部疾病小动物模型的神经成像。在本文中，我们概述了用于血流成像的OCTA技术的最新发展及其在神经成像中的临床前应用。具体而言，本文回顾了针对小鼠创伤性脑损伤、脑卒中和衰老大脑的临床前OCTA研究总结。
