Kolb Jan Philip, Pfeiffer Tom, Eibl Matthias, Hakert Hubertus, Huber Robert
Institut für Biomedizinische Optik, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Biomed Opt Express. 2017 Dec 5;9(1):120-130. doi: 10.1364/BOE.9.000120. eCollection 2018 Jan 1.
We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2∙ 417 kHz = 834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 µm axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 nm sweep range, as well as to existing spectral domain OCT data with 2.1 µm axial resolution from literature. We identify benefits of the higher resolution, for example the improved visualization of small blood vessels in the retina besides several others.
我们展示了一种新型的1060纳米傅里叶域锁模激光器（FDML激光器），在2∙417千赫兹 = 834千赫兹时具有创纪录的143纳米扫描带宽，在1.67兆赫兹时分别为120纳米。我们表明，由于玻璃体特定的波长依赖性吸收，不仅带宽，而且光谱形状对于最终的轴向分辨率也至关重要。我们装置的理论极限为5.9微米轴向分辨率。对人类视网膜进行了体内兆赫兹光学相干断层扫描（MHz - OCT）成像，并将图像质量与之前用70纳米扫描范围获得的结果以及文献中轴向分辨率为2.1微米的现有光谱域光学相干断层扫描数据进行了比较。我们确定了更高分辨率的益处，例如除了其他几个方面外，还改善了视网膜中小血管的可视化。
