University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195, United States; University of Washington, Department of Electrical Engineering, 185 Stevens Way, Seattle, Washington 98195, United States.
University of Washington , Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195, United States.
Neurophotonics. 2016 Jan;3(1):010902. doi: 10.1117/1.NPh.3.1.010902. Epub 2016 Jan 20.
The brain is a complex ecosystem, consisting of multiple layers and tissue compartments. To facilitate the understanding of its function and its response to neurological insults, a fast in vivo imaging tool with a micron-level resolution, which can provide a field of view at a few millimeters, is desirable. Optical coherence tomography (OCT) is a noninvasive method for imaging three-dimensional biological tissues with high resolution ([Formula: see text]) and without a need for contrast agents. Recent development of OCT-based angiography has started to shed some new light on cerebral hemodynamics in neuroscience. We give an overview of the recent developments of OCT-based imaging techniques for neuroscience applications in rodents. We summarize today's technological alternatives for OCT-based angiography for neuroscience and provide a discussion of challenges and opportunities. Moreover, a summary of OCT angiography studies for stroke, traumatic brain injury, and subarachnoid hemorrhage cases on rodents is provided.
大脑是一个复杂的生态系统，由多个层次和组织隔室组成。为了促进对其功能及其对神经损伤的反应的理解，需要一种具有微米级分辨率的快速活体成像工具，该工具能够提供几毫米的视场。光学相干断层扫描（OCT）是一种非侵入性的方法，可对具有高分辨率（[公式：见文本]）的三维生物组织进行成像，而无需造影剂。基于 OCT 的血管造影术的最新发展开始为神经科学中的脑血流动力学提供一些新的见解。我们概述了基于 OCT 的成像技术在啮齿动物神经科学应用中的最新发展。我们总结了用于神经科学的基于 OCT 的血管造影术的当前技术选择，并讨论了挑战和机遇。此外，还提供了关于啮齿动物中风、创伤性脑损伤和蛛网膜下腔出血病例的 OCT 血管造影研究的摘要。
