Shimanuki Chisato, Matsuta Yuuma, Fujita Ryo, Kumaki Jiro
Department of Polymer Science and Engineering, Faculty of Engineering, Department of Polymer Science and Engineering, Graduate School of Engineering and Science, and Department of Organic Materials Science, Graduate School of Organic Materials Science, Yamagata University, Yonezawa, Yamagata 992-8510, Japan.
ACS Omega. 2018 Apr 10;3(4):3983-3990. doi: 10.1021/acsomega.8b00325. eCollection 2018 Apr 30.
If polymer chains could be fixed on a substrate as a fully elongated chain, a procedure known as "", the chain structure could be analyzed more precisely than has been possible with the characterization techniques available today. Although the molecular combing of a rigid biomolecule, DNA, has been attained for the mapping of genetic information, that of flexible chains has never been achieved as yet. We show here that poly(-nonyl acrylate) (PNA) can be molecularly combed on mica by a simple spin-casting method, and that the chain lengths were in good agreement with that of the all-trans conformation. One of the key factors for successful molecular combing was found to be the weak adsorption of PNA on mica, indicating that flexible polymers may be molecularly combed by adjusting their affinity to the substrate. The molecular combing of polymer chains may open a new way not only to characterize the chain structures more precisely but also to fabricate new nanomaterials based on polymers.
如果聚合物链能够以完全伸展的链形式固定在基底上，这一过程称为“ ”，那么与目前可用的表征技术相比，链结构能够得到更精确的分析。尽管刚性生物分子DNA的分子梳理已用于遗传信息的图谱绘制，但柔性链的分子梳理至今尚未实现。我们在此表明，聚（壬基丙烯酸酯）（PNA）可以通过简单的旋涂法在云母上进行分子梳理，且链长与全反式构象的链长高度一致。成功进行分子梳理的关键因素之一是PNA在云母上的弱吸附，这表明通过调节柔性聚合物与基底的亲和力，有可能对其进行分子梳理。聚合物链的分子梳理不仅可能为更精确地表征链结构开辟一条新途径，还可能为基于聚合物制造新型纳米材料开辟新途径。
