Dong Jian-Lian, Yu Li-Si-Han, Xie Jian-Wu
Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, P. R. China.
ACS Omega. 2018 May 7;3(5):4974-4985. doi: 10.1021/acsomega.8b00159. eCollection 2018 May 31.
An important and surprising finding that the acetalization and ketalization of aldehydes and ketones with alcohols, respectively, proceed smoothly in the presence of 0.1 mol % acid, without removing water, has been presented. This process has many merits, such as commercial available catalysts with low cost and low loadings (as low as 0.03 mol %), quite a broad substrate scope (including various aldehydes, ketones, acid-sensitive substrates, and diols), a wide range of reaction temperature (-60 to 50 °C), high yields, large-scale preparation, environmental friendliness, and simple work-up procedure. This new protocol has also been successfully applied to protect the important organic compounds, such as 1,3-diols, 1,2-diols, acid-sensitive substrates, glucose, and 1,3-dicarbonyl compounds.
醛和酮分别与醇的缩醛化和缩酮化反应在0.1 mol%的酸存在下能顺利进行，无需除水。该过程具有许多优点，如使用低成本、低负载量（低至0.03 mol%）的市售催化剂，底物范围相当广泛（包括各种醛、酮、酸敏感底物和二醇），反应温度范围宽（-60至50°C），产率高，可大规模制备，环境友好且后处理程序简单。这种新方法也已成功应用于保护重要的有机化合物，如1,3 - 二醇、1,2 - 二醇、酸敏感底物、葡萄糖和1,3 - 二羰基化合物。
