基于氯喹的线粒体 ATP 抑制剂。

Department of Chemistry and Biochemistry, The University of Tulsa, 430 South Gary Place, Tulsa, OK 74104, USA.

Molecules. 2023 Jan 24;28(3):1161. doi: 10.3390/molecules28031161.

Mitochondria is an important drug target for ailments ranging from neoplastic to neurodegenerative diseases and metabolic diseases. Here, we describe the synthesis of chloroquine analogs and show the results of mitochondrial ATP inhibition testing. The 2,4-dinitrobenzene-based analogs showed concentration-dependent mitochondrial (mito.) ATP inhibition. The most potent mito. ATP inhibitor was found to be -(4-((2,4-Dinitrophenyl)amino)pentyl)--ethylacetamide ().

线粒体是从肿瘤到神经退行性疾病和代谢疾病等各种疾病的重要药物靶点。在这里，我们描述了氯喹类似物的合成，并展示了线粒体 ATP 抑制测试的结果。基于 2,4-二硝基苯的类似物表现出浓度依赖性的线粒体（mito.）ATP 抑制。发现最有效的 mito.ATP 抑制剂为-(4-((2,4-二硝基苯基)氨基)戊基)-乙基乙酰胺（）。