More Santosh R, Yadav Ganapati D
Department of Chemical Engineering, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400 019, India.
ACS Omega. 2018 Jun 29;3(6):7124-7132. doi: 10.1021/acsomega.8b00001. eCollection 2018 Jun 30.
1-Phenylethanol (PhE) is widely employed in the pharmaceutical industry as an anti-inflammatory and analgesic drug, as well as in chewing gums and yogurts as a food additive. In this work, we have investigated the selective synthesis of 1-phenylethanol (PhE) by hydrogenation of acetophenone using supercritical CO as a solvent. Supercritical carbon dioxide (scCO) replaces organic solvent because it is inexpensive, nontoxic, nonflammable, inert, and environmentally benign. Polyurea-based encapsulated mono- and bimetallic catalysts were synthesized and characterized using different characterization techniques. The effects of various reaction parameters, such as co-solvent, catalyst loading, hydrogen pressure, total scCO pressure, and temperature, were studied to determine the reaction kinetics.
1-苯乙醇（PhE）在制药行业中被广泛用作抗炎和镇痛药，同时在口香糖和酸奶中作为食品添加剂使用。在这项工作中，我们研究了以超临界CO作为溶剂，通过苯乙酮加氢选择性合成1-苯乙醇（PhE）。超临界二氧化碳（scCO₂）替代了有机溶剂，因为它价格低廉、无毒、不可燃、惰性且对环境友好。合成了基于聚脲的单金属和双金属封装催化剂，并使用不同的表征技术对其进行了表征。研究了各种反应参数，如共溶剂、催化剂负载量、氢气压力、总scCO₂压力和温度的影响，以确定反应动力学。
