Dlim Marwa M, Shahout Fatma S, Khabir Marwa K, Labonté Patrick P, LaPlante Steven R
INRS, Institut Armand-Frappier, Université du Québec, 531, boul. des Prairies, Laval, Québec H7V 1B7, Canada.
ACS Omega. 2019 May 23;4(5):8919-8925. doi: 10.1021/acsomega.9b00667. eCollection 2019 May 31.
The aqueous properties of the drugs Sorafenib, Lapatinib, Gefitinib, Fulvestrant, and Clofazimine were explored to monitor their tendency to self-associate. A combination of nuclear magnetic resonance, dynamics light scattering, and electron and confocal microscopies found that they tended to form large nano-entities having distinct types and sizes and were capable of entering cells. The combination of strategies employed serves to detect and reveal nano-entities along with their three-state equilibria and behaviors in buffers, media, and cells.
研究了索拉非尼、拉帕替尼、吉非替尼、氟维司群和氯法齐明等药物的水性性质，以监测它们的自缔合倾向。核磁共振、动态光散射以及电子显微镜和共聚焦显微镜相结合的方法发现，它们倾向于形成具有不同类型和大小的大型纳米实体，并且能够进入细胞。所采用的多种策略相结合，有助于检测和揭示纳米实体及其在缓冲液、培养基和细胞中的三态平衡与行为。
