通过1-氨基-2-亚氨基吡啶与1-芳基-5-吡唑啉酮之间的无金属催化剂有氧C(sp)-C(sp)偶联反应合成（吡唑-4-亚基）吡啶的可持续方法

Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp)-C(sp) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones.

作者信息

Ibrahim Hamada Mohamed, Behbehani Haider

机构信息

Chemistry Department, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.

Chemistry Department, Faculty of Science, Fayoum University, P.O. Box 63514, Fayoum, Egypt.

出版信息

ACS Omega. 2019 Jul 5;4(7):11701-11711. doi: 10.1021/acsomega.9b01650. eCollection 2019 Jul 31.

A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene)pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5-pyrazolone derivatives utilizing O as the sole oxidant. The new method benefits from a high atom economy, efficiency, and substrate scope, as well as the simplicity of reaction and product purification procedures.