通过动态动力学拆分制备()-2-氨基-5,5,5-三氟戊酸的实用方法。
Practical Method for Preparation of ()-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution.
作者信息
Mei Haibo, Han Jianlin, Takeda Ryosuke, Sakamoto Tsubasa, Miwa Toshio, Minamitsuji Yutaka, Moriwaki Hiroki, Abe Hidenori, Soloshonok Vadim A
机构信息
College of Chemical Engineering Nanjing Forestry University, Nanjing 210037, China.
Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
出版信息
ACS Omega. 2019 Jul 9;4(7):11844-11851. doi: 10.1021/acsomega.9b01537. eCollection 2019 Jul 31.
Abstract
This work reports an operationally convenient ∼20 g scale synthesis of ()-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.
摘要
本研究报告了一种操作简便的约20克规模的合成方法，通过相应外消旋体的动态动力学拆分合成（）-2-氨基-5,5,5-三氟戊酸及其Fmoc衍生物。
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