两性霉素B甲酯：用于实验性真菌性眼内炎玻璃体腔内注射的评估
Amphotericin B methyl ester: evaluation for intravitreous use in experimental fungal endophthalmitis.
作者信息
McGetrick J J, Peyman G A, Nyberg M A
出版信息
Ophthalmic Surg. 1979 Jul;10(7):25-9.
PMID:314613
Abstract
Amphotericin B methyl ester, a water-soluble derivative of amphotericin B, is an experimental antifungal agent. Intravitreous injection of 5 and 10 micrograms of amphotericin B methyl ester in the normal rabbit eye does not cause toxic changes that can be detected clinically, microscopically, or by electroretinography. A single intravitreous injection of 5 micrograms was effective in reversing the course of exogenous Candida fungal endophthalmitis when administered within five days after inoculation of the infecting organism.
摘要
两性霉素B甲酯是两性霉素B的一种水溶性衍生物，是一种实验性抗真菌药物。在正常兔眼玻璃体内注射5微克和10微克两性霉素B甲酯不会引起临床上、显微镜下或视网膜电图检测到的毒性变化。在接种感染生物体后五天内给予5微克玻璃体内单次注射可有效逆转外源性念珠菌性真菌性眼内炎的病程。
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